Embryology.
Embryology.
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DOI：
10.1016/b978-0-444-63956-1.00002-3
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发表时间：
2018-01-01
影响因子：
--
通讯作者：
Millen, Kathleen J
中科院分区：
文献类型：
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作者：
Haldipur, Parthiv;Dang, Derek;Millen, Kathleen J
随着对人类小脑疾病的程度和患病率的日益认识，了解建立成熟小脑的发育程序是必要的。在这一章中，我们提出了一个概述的基本时期和关键的分子调节小脑发育的发展计划。这些包括小脑领域的早期模式，小脑细胞从多个空间上不同的生发区的起源，以及广泛的迁移和协调的细胞重排，导致形成精美的叶状和层状成熟小脑。这一知识基础是建立在对动物模型，特别是小鼠的广泛分析基础上的，这在很大程度上是因为这种重要的模型生物易于遗传操作。由于小脑的结构和功能在很大程度上是保守的物种，小鼠小脑的发展是高度相关的人类，并导致了重要的见解人类小脑疾病的发育发病机制。人类胎儿小脑发育在很大程度上仍未描述;然而，已知几个人类特异性发育特征与人类疾病相关，并强调了正在进行的人类胎儿研究的重要性。
With the growing recognition of the extent and prevalence of human cerebellar disorders, an understanding of developmental programs that build the mature cerebellum is necessary. In this chapter we present an overview of the basic epochs and key molecular regulators of the developmental programs of cerebellar development. These include early patterning of the cerebellar territory, the genesis of cerebellar cells from multiple spatially distinct germinal zones, and the extensive migration and coordinated cellular rearrangements that result in the formation of the exquisitely foliated and laminated mature cerebellum. This knowledge base is founded on extensive analysis of animal models, particularly mice, due in large part to the ease of genetic manipulation of this important model organism. Since cerebellar structure and function are largely conserved across species, mouse cerebellar development is highly relevant to humans and has led to important insights into the developmental pathogenesis of human cerebellar disorders. Human fetal cerebellar development remains largely undescribed; however, several human-specific developmental features are known which are relevant to human disease and underline the importance of ongoing human fetal research.