Oral administration of antigen can lead to the onset of autoimmune disease.
Oral administration of antigen can lead to the onset of autoimmune disease.
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DOI：
10.3109/08830189909043026
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发表时间：
1999-01-01
影响因子：
5
通讯作者：
Heath, W R
中科院分区：
文献类型：
--
作者：
Blanas, E;Heath, W R
已知口服抗原可诱导对同一抗原的后续攻击产生特异性免疫无反应状态。基于此，口服自体抗原已被应用于治疗人类自身免疫性疾病，如类风湿关节炎和多发性硬化症。诱导口服耐受性的确切机制尚不清楚。为了解决这个问题，我们已经用卵清蛋白（OVA）作为模型抗原，培育了几系转基因小鼠。我们的研究表明，口服抗原可诱导细胞毒性T淋巴细胞反应，这可能导致自身免疫性疾病的发生。这些发现表明，当口服抗原用于治疗人类自身免疫性疾病时，应谨慎使用。
Oral administration of antigen is known to induce a state of specific immunological unresponsiveness to a subsequent challenge with the same antigen. Based on this, oral delivery of autoantigens has been applied as a possible strategy for the treatment of human autoimmune diseases like rheumatoid arthritis and multiple sclerosis. The precise mechanisms involved in the induction of oral tolerance are yet to be clearly defined. In an attempt to address this issue, we have generated several lines of transgenic mice using ovalbumin (OVA) as the model antigen. Our studies have shown that a cytotoxic T lymphocyte response could be induced by oral administration of antigen and that this could lead to the onset of autoimmune disease. These findings suggest caution should be applied when oral administration of antigen is used to treat human autoimmune diseases.