Use of the cockroach antigen model of acute asthma to determine the immunomodulatory role of early exposure to gastrointestinal infection.
Use of the cockroach antigen model of acute asthma to determine the immunomodulatory role of early exposure to gastrointestinal infection.
复制标题
使用急性哮喘蟑螂抗原模型来确定早期接触胃肠道感染的免疫调节作用。
DOI：
10.1007/978-1-62703-496-8_21
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Lorenz,RobinG
中科院分区：
文献类型：
--
作者：
Durham,CarolynG;Schwiebert,LisaM;Lorenz,RobinG
发达国家在过去50年中哮喘发病率的增加与儿童早期感染的减少有关。这些早期感染被认为影响了随后的免疫反应。尽管胃肠道感染与哮喘发病率下降之间存在多种临床关联，但在研究人类患者时，很难超越简单的关联。本部分描述了一种C57BL/6小鼠急性哮喘模型，旨在专门评估先前胃肠道幽门螺杆菌定植和炎症对蟑螂变应原诱导哮喘小鼠模型的影响。
The increased incidence of asthma over the last 50 years in developed countries has been associated with a decrease in infections acquired early in childhood. These early infections are thought to shape subsequent immune responses. Although there have been multiple clinical associations between gastrointestinal infections and decreased asthma incidence, it has been difficult to move beyond a simple correlation when studying human patients. This section describes an acute asthma model in C57BL/6 mice designed to specifically evaluate the effect of prior gastricHelicobactercolonization and inflammation in a murine model of cockroach allergen-induced asthma.