Increased resistance to Taenia crassiceps murine cysticercosis in Qa-2 transgenic mice
Increased resistance to Taenia crassiceps murine cysticercosis in Qa-2 transgenic mice
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DOI：
10.1128/iai.66.2.760-764.1998
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发表时间：
1998-02-01
影响因子：
3.1
通讯作者：
Sciutto, E
中科院分区：
文献类型：
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作者：
Fragoso, G;Lamoyi, E;Sciutto, E
我们以前报告的重要差异，抗带绦虫粗头蚴鼠囊尾蚴病之间的BALB/c亚株。结果表明，BALB/cAnN对T.在本研究中，我们通过连锁分析和感染Qa-2转基因小鼠来研究Qa-2在介导抗囊虫病中的作用。在BALB/cAnN ×（C57 BL/6 J × BALB/cAnN）F-1和BALB/cAnN ×（BALB/cJ × BALB/cAnN）F-1回交中，Qa-2抗原的表达与抗囊虫病相关。从感染的Qa-2转基因雄性和雌性小鼠中回收的寄生虫显著少于从相似遗传背景的非转基因小鼠中回收的寄生虫。这些结果清楚地表明，Qa-2 MHC抗原参与对T.粗头囊虫病
We previously reported important differences in resistance to Taenia crassiceps murine cysticercosis between BALB/c substrains. It was suggested that resistance might correlate with expression of the nonclassic class I major histocompatibility complex (MHC) Qa-2 antigen; BALB/cAnN is Qa-2 negative and highly susceptible to T. crassiceps, whereas BALB/cJ expresses Qa-2 and is highly resistant, In this study, we investigated the role of Qa-2 in mediating resistance to cysticercosis by linkage analysis and infection of Qa-2 transgenic mice. In BALB/cAnN x (C57BL/6J x BALB/cAnN)F-1, and BALB/cAnN x (BALB/cJ x BALB/cAnN)F-1 backcrosses, the expression of Qa-2 antigen correlated with resistance to cysticercosis. Significantly fewer parasites recovered from infected Qa-2 transgenic male and female mice than from nontransgenic mice of similar genetic background. These results clearly demonstrate that the Qa-2 MHC antigen is involved in resistance to T. crassiceps cysticercosis.