Morphological analysis of age-related iridocorneal angle changes in normal and glaucomatous cases using anterior segment optical coherence tomography.
Morphological analysis of age-related iridocorneal angle changes in normal and glaucomatous cases using anterior segment optical coherence tomography.
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DOI：
10.2147/opth.s52370
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Kinoshita S
中科院分区：
文献类型：
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作者：
Maruyama Y;Mori K;Ikeda Y;Ueno M;Kinoshita S
使用眼前节光学相干断层扫描（AS-OCT）分析正常受试者和青光眼病例中与年龄相关的虹膜角膜角形态变化。这项研究涉及 58 名开角型青光眼病例的 58 只眼睛和 72 名年龄匹配的正常开角型对照受试者的 72 只眼睛。使用 AS-OCT 测量鼻部和颞部区域的虹膜角膜角结构以及前房深度 (ACD)。使用眼生物计和自动验光角膜曲率计测量眼轴长度和屈光不正。计算鼻部和颞部区域距巩膜骨刺 500 μm (TISA500) 和 750 μm (TISA750) 处的开角距离 (AOD)、角凹进面积 (ARA) 和小梁虹膜间隙面积 (TISA)。提出了一种代表周边角结构的新指标——周边角框架指数（PAFI），并定义为（TISA750-TISA500）/TISA500。青光眼病例的屈光力低于对照病例（P<0.0001）。与对照病例相比，青光眼病例的眼轴长度（P<0.0001）和ACD（P=0.0004）分别更长和更深。在对照组和青光眼组中，ACD、AOD、ARA 和 TISA 均以年龄依赖性方式线性下降，而 PAFI 在整个年龄分布中保持相对恒定的值。青光眼组的颞区和鼻区 AOD 均比对照组长；青光眼组中的 ARA 和 TISA 比对照组更大。然而，青光眼组和对照组之间鼻部或颞部 PAFI 没有显着差异。本研究的结果表明，AS-OCT 可用于定量评估青光眼和对照病例中与年龄相关的周边角结构变化。
To analyze age-related morphological changes of the iridocorneal angle in normal subjects and glaucomatous cases, using anterior segment optical coherence tomography (AS-OCT). This study involved 58 eyes of 58 open-angle glaucoma cases and 72 eyes of 72 age-matched normal-open-angle control subjects. Iridocorneal angle structures in nasal and temporal regions and anterior chamber depth (ACD) were measured using AS-OCT. Axial length and refractive error were measured by use of an ocular biometer and auto refractor keratometer. Angle opening distance (AOD), angle recess area (ARA), and trabecular-iris space area (TISA), measured at 500 μm (TISA500) and 750 μm (TISA750) distant from the scleral spur, were calculated, in the nasal and temporal regions. A new index, the peripheral angle frame index (PAFI), which represents the peripheral angle structure, was proposed, and was defined as (TISA750-TISA500)/TISA500. Refractive power in the glaucoma cases was less than in control cases (P<0.0001). Axial length (P<0.0001) and ACD (P=0.0004) were longer and deeper, respectively, in the glaucoma cases, compared with the control cases. In both control and glaucoma groups, ACD, AOD, ARA, and TISA decreased linearly in an age-dependent manner, while PAFI stayed at relatively constant values throughout the age distribution. AOD in the glaucoma group was longer than in the control group, in both the temporal and nasal regions; ARA and TISA were larger in the glaucoma than in the control group. However, no significant differences in nasal or temporal PAFI were found between the glaucoma and control groups. The findings of this study show that AS-OCT is useful for the quantitative evaluation of age-related changes in peripheral angle structure in glaucoma and control cases.