Alzheimer's disease, dementia, and stem cell therapy.
Alzheimer's disease, dementia, and stem cell therapy.
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DOI：
10.1186/s13287-017-0567-5
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发表时间：
2017-05-12
影响因子：
7.5
通讯作者：
Valenzuela M
中科院分区：
文献类型：
--
作者：
Duncan T;Valenzuela M
阿尔茨海默病(AD)可以说是我们这个时代最严重的社会、经济和医疗危机。阿尔茨海默病以进行性神经退行性病变为特征，首先是神经元和突触丢失。因此，通过外源干细胞再生枯竭的神经元回路是一种合理的治疗策略。这篇综述将集中于利用AD动物模型的干细胞疗法的最新进展，以及目前正在开发的AD干细胞疗法的人类临床试验。
Alzheimer’s disease (AD) represents arguably the most significant social, economic, and medical crisis of our time. Characterized by progressive neurodegenerative pathology, AD is first and foremost a condition of neuronal and synaptic loss. Repopulation and regeneration of depleted neuronal circuitry by exogenous stem cells is therefore a rational therapeutic strategy. This review will focus on recent advances in stem cell therapies utilizing animal models of AD, as well as detailing the human clinical trials of stem cell therapies for AD that are currently undergoing development.