ENDOTHELIN IN THE CENTRAL CONTROL OF CARDIOVASCULAR AND RESPIRATORY FUNCTIONS
ENDOTHELIN IN THE CENTRAL CONTROL OF CARDIOVASCULAR AND RESPIRATORY FUNCTIONS
复制标题
内皮素在心血管和呼吸功能的中央控制中的作用
DOI：
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发表时间：
1999
影响因子：
2.9
通讯作者：
Y. Fukuda
中科院分区：
文献类型：
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作者：
T. Kuwaki;Gy Ling;M. Onodera;T. Ishii;A. Nakamura;Kh Ju;Wh Cao;M. Kumada;H. Kurihara;Y. Kurihara;Y. Yazaki;T. Ohuchi;M. Yanagisawa;Y. Fukuda
1.外源性内皮素（ET）调节中枢神经系统（CNS）中心血管和呼吸神经元的活动，从而影响动脉血压（ABP）和通气。然而，内源性ET在CNS中的生理作用尚未阐明。为了解决这个问题，我们在ET-1、ETA和ETB受体以及内皮素转换酶-1缺陷的突变小鼠中检查了ABP和通气，这些突变小鼠是通过基因靶向制备的。
1. Exogenously administered endothelin (ET) modulates the activity of cardiovascular and respiratory neurons in the central nervous system (CNS) and, thus, affects arterial blood pressure (ABP) and ventilation. However, a physiological role(s) for endogenous ET in the CNS has not been elucidated. To address this question, we examined ABP and ventilation in mutant mice deficient in ET‐1, ETA and ETB receptors and endothelin‐ converting enzyme‐1, which were made by gene targeting.