Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration
Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration
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DOI：
10.1038/nature02301
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发表时间：
2004-02-19
期刊：
影响因子：
64.8
通讯作者：
Alvarez-Buylla, A
中科院分区：
文献类型：
--
作者：
Sanai, N;Tramontin, AD;Alvarez-Buylla, A
脑室下区（SVZ）是啮齿动物大脑中成体神经干细胞的主要来源，每天产生数千个嗅球神经元（1）。如果成年人的大脑包含一个类似的germinal区域，这可能对未来的神经再生疗法产生相当大的影响。干细胞已从人脑中分离出来（2-7），但人类SVZ中成人神经干细胞的身份、组织和功能尚不清楚。在这里，我们描述了一个带状SVZ星形胶质细胞内衬侧脑室的成人大脑，在体内增殖，并在体外表现为多能祖细胞。这种星形胶质细胞带在其他研究的脊椎动物中尚未观察到。出乎意料的是，我们没有发现任何证据的链迁移成神经细胞在SVZ或在通路的嗅球。我们的工作确定SVZ星形胶质细胞作为神经干细胞在一个独特的组织在成人大脑的利基。
The subventricular zone (SVZ) is a principal source of adult neural stem cells in the rodent brain, generating thousands of olfactory bulb neurons every day(1). If the adult human brain contains a comparable germinal region, this could have considerable implications for future neuroregenerative therapy. Stem cells have been isolated from the human brain(2-7), but the identity, organization and function of adult neural stem cells in the human SVZ are unknown. Here we describe a ribbon of SVZ astrocytes lining the lateral ventricles of the adult human brain that proliferate in vivo and behave as multipotent progenitor cells in vitro. This astrocytic ribbon has not been observed in other vertebrates studied. Unexpectedly, we find no evidence of chains of migrating neuroblasts in the SVZ or in the pathway to the olfactory bulb. Our work identifies SVZ astrocytes as neural stem cells in a niche of unique organization in the adult human brain.