Increasing heterogeneity in the organization of synaptic inputs of mature olfactory bulb neurons generated in newborn rats
Increasing heterogeneity in the organization of synaptic inputs of mature olfactory bulb neurons generated in newborn rats
复制标题
新生大鼠产生的成熟嗅球神经元突触输入组织的异质性增加
DOI：
10.1002/cne.22799
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发表时间：
2012
影响因子：
2.5
通讯作者：
Lois C
中科院分区：
文献类型：
--
作者：
Kelsch W;Lois C
哺乳动物的嗅球在整个生命过程中都会增加新的神经元，但尚不清楚新生动物产生的新神经元的性质是否与成年动物增加的不同。我们比较了新生大鼠和成年大鼠在较长时间内产生的颗粒细胞(GC)谷氨酸能突触的密度。我们观察到，尽管成年出生的GC在整合到环路后不久就保持了稳定的细胞间突触密度的可变性，但新生儿出生的GCs在整合几个月后细胞间的突触密度的可变性增加。我们还研究了感觉剥夺诱导的突触重组在成熟的新生儿和成人出生的GC中是否发生了不同的情况。在新生的GCs分化后，感觉剥夺导致新生儿出生的GCs的突触密度比成年出生的GCs更显著的变化。这些观察表明，与成年出生的GC相比，成熟的新生儿出生的GC的突触保持了更高程度的延展性，以响应神经元活动的变化。J.Comp.神经。520：1327-1338,2012。©2011 Wiley期刊，Inc.
New neurons are added into the mammalian olfactory bulb throughout life, but it remains unknown whether the properties of new neurons generated in newborn animals differ from those added during adulthood. We compared the densities of glutamatergic synapses of granule cells (GCs) generated in newborn and adult rats over extended periods of time. We observed that, whereas adult‐born GCs maintained stable cell‐to‐cell variability of synaptic densities soon after they integrated into the circuit, cell‐to‐cell variability of synaptic densities of neonatal‐born GCs increased months after their integration. We also investigated whether the synaptic reorganization induced by sensory deprivation occurred differently in mature neonatal‐ and adult‐born GCs. Sensory deprivation after new GCs had differentiated induced more pronounced changes in the synaptic densities of neonatal‐born GCs than in adult‐born GCs. These observations suggest that the synapses of mature neonatal‐born GCs retain a higher degree of malleability in response to changes in neuronal activity than adult‐born GCs. J. Comp. Neurol. 520:1327–1338, 2012. © 2011 Wiley Periodicals, Inc.