Three-dimensional saturation transfer ³¹P-MRI in muscles of the lower leg at 3.0 T.
Three-dimensional saturation transfer ³¹P-MRI in muscles of the lower leg at 3.0 T.
复制标题
3.0 T 下小腿肌肉的三维饱和度传输 P-MRI。
DOI：
10.1038/srep05219
复制
发表时间：
2014
影响因子：
4.6
通讯作者：
Regatte,RavinderR
中科院分区：
文献类型：
--
作者：
Parasoglou,Prodromos;Xia,Ding;Chang,Gregory;Regatte,RavinderR
The creatine kinase (CK) reaction plays a critical role in skeletal muscle function and can be studied non-invasively using phosphorus (31P) saturation transfer (ST) techniques. However, due to the low MR sensitivity of the31P nucleus, most studies on clinically approved magnetic fields (≤3.0 T) have been performed with coarse resolution and limited tissue coverage. However, such methods are not able to detect spatially resolved metabolic heterogeneities, which may be important in diseases of the skeletal muscle. In this study, our aim was to develop and implement a31P-MRI method for mapping the kinetics of the CK reaction and the unidirectional phosphocreatine (PCr) to adenosine triphosphate (ATP) metabolic fluxes in muscles of the lower leg on a clinical 3.0 T MR scanner. We imaged the lower leg muscles of ten healthy volunteers (total experimental time: 40 min, nominal voxel sizes 0.5 mL) and found statistically significant differences between the kinetics of the CK reaction among muscle groups. Our developed technique may allow in the future the early detection of focal metabolic abnormalities in diseases that affect the function of the skeletal muscle.
