Antibacterial peptides "bacteriocins": an overview of their diverse characteristics and applications.
Antibacterial peptides "bacteriocins": an overview of their diverse characteristics and applications.
复制标题
DOI：
10.4265/bio.17.1
复制
发表时间：
2012-03
影响因子：
1.2
通讯作者：
M. Nishie;Jun-ichi Nagao;K. Sonomoto
中科院分区：
文献类型：
--
作者：
M. Nishie;Jun-ichi Nagao;K. Sonomoto
细菌素是细菌产生的核糖体合成抗菌肽，可抑制相似或密切相关的细菌菌株的生长。已经发现了来自多种细菌的多种细菌素，并报道了它们的不同结构。越来越多的证据表明细菌素具有不同的结构、作用方式、生物合成和自身免疫机制以及基因调控。细菌素被认为是食品和制药行业中一种有吸引力的化合物，可防止食品腐败和致病细菌生长。此外，对其生物合成的阐明导致使用细菌素控制的基因表达系统和羊毛硫抗生素（一类细菌素）的生物合成酶作为设计新型肽的工具。在这篇综述中，我们总结并讨论了目前已知的有关革兰氏阳性菌产生的细菌素及其应用的信息。
Bacteriocins are ribosomally synthesized antibacterial peptides produced by bacteria that inhibit the growth of similar or closely related bacterial strains. A number of bacteriocins from a wide variety of bacteria have been discovered, and their diverse structures have been reported. Growing evidence suggests that bacteriocins have diverse structures, modes of action, mechanisms of biosynthesis and self-immunity, and gene regulation. Bacteriocins are considered as an attractive compound in food and pharmaceutical industries to prevent food spoilage and pathogenic bacterial growth. Furthermore, elucidation of their biosynthesis has led to the use of bacteriocin-controlled gene-expression systems and the biosynthetic enzymes of lantibiotics, a class of bacteriocins, as tools to design novel peptides. In this review, we summarize and discuss currently known information on bacteriocins produced by Gram-positive bacteria and their applications.