Assessment of Pulmonary Flow Using Impedance Pneumography
Assessment of Pulmonary Flow Using Impedance Pneumography
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DOI：
10.1109/tbme.2010.2051668
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发表时间：
2010-09-01
影响因子：
4.6
通讯作者：
Hyttinen, Jari
中科院分区：
文献类型：
--
作者：
Seppa, Ville-Pekka;Viik, Jari;Hyttinen, Jari
尽管潮汐呼吸分析已被证明包含与气道阻塞程度相关的信息，但缺乏适合于连续长期测量活动受试者潮汐呼吸的无创肺功能测量技术。本文首次评估了阻抗肺造影（IP）测量连续肺流量和容积信号的适用性，而不仅仅是呼吸速率（RR）或潮气量（V-T）。我们同时测量了20名健康男性受试者的PNT和IP信号，他们分别处于直立、仰卧和侧卧位置，同时自愿改变V-T。测量IP使用五种不同的阻抗引线配置，电极集成在纺织胸带中。将IP信号与PNT信号进行比较，以更完善的测量方法评估IP的一致性。采用时差IP信号与PNT信号的测量标准误差（SEM） rho = 1-SEM来评估肺血流信号波形的一致性。此外，我们评估了IP和PNT在V-T估计中的一致性以及阻抗信号中存在的心源性振荡的幅度。在所有潮气量和体位下，肺血流信号波形形状的一致性非常好（平均rho > 0.90）。当每个受试者和姿势校准IP值时，pnt衍生的V-T估计值与IP衍生的V-T估计值之间的一致性非常高（平均差异< 3%）。心源性畸变是目视检测IP信号误差的主要来源。通过对5种新型电极配置的测试，发现侧位电极明显优于正位电极。IP有可能开发出一种无创动态测量设备，用于长期研究移动受试者的某些潮汐呼吸参数。
There is a lack of noninvasive pulmonary function measurement techniques suitable for continuous long-term measurement of tidal breathing in mobile subjects, although tidal breathing analysis has been shown to contain information that relates to the level airway obstruction. This paper is the first to assess the suitability of impedance pneumography (IP) for measurement of continuous pulmonary flow and volume signals instead of only the respiration rate (RR) or tidal volume (V-T). We measured pneumotachograph (PNT) and IP signals simultaneously from 20 healthy male subjects in erect, dorsal supine, and lateral supine positions while voluntarily varying V-T. IP was measured using five different impedance lead configurations with electrodes integrated into a textile chest belt. The IP signals were compared with PNT signals to assess agreement of IP with a more well-established measurement method. The pulmonary flow signal waveform agreement was assessed with standard error of measurement (SEM) between the time-differentiated IP signal and the PNT signal as rho = 1-SEM. Additionally, we assessed the agreement of IP and PNT in V-T estimation and the magnitude of the cardiogenic oscillation present in the impedance signal. The agreement in the pulmonary flow signal waveform shapes was found excellent at all tidal volumes and postures (mean rho > 0.90). The agreement between the PNT-derived and the IP-derived V-T estimates was very high when IP values were calibrated per subject and posture (mean difference < 3%). The main source of error in visual inspection of the IP signal was the cardiogenic distortion. From the five novel electrode configurations tested, the lateral ones were found clearly better than the anteroposterior ones. IP potentially enables the development of a noninvasive ambulatory measurement device for long-term studies of certain tidal breathing parameters in mobile subjects.