Anterior cingulate volume in pediatric bipolar disorder and autism
Anterior cingulate volume in pediatric bipolar disorder and autism
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DOI：
10.1016/j.jad.2007.04.019
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发表时间：
2008-01-01
影响因子：
6.6
通讯作者：
Hendren, Robert L.
中科院分区：
文献类型：
--
作者：
Chiu, Sufen;Widjaja, Felicia;Hendren, Robert L.
背景：越来越多的研究表明，扣带回前部(ACG)可能在儿童双相情感障碍(BD)的注意缺陷中起作用。年龄、药物和智商(IQ)可能会影响ACG的体积，但很少有研究对这些影响进行控制。方法：我们招募了16名儿童(131名)和24名自闭症谱系障碍(ASD)儿童，15名没有精神诊断(NP)的儿童也包括在内。所有参与者都接受了K-SADS和DSM-IV自闭症/阿斯伯格检查表的评估；研究开始后不久，ADI-R也被应用于ASD参与者。参与者在1.5Tesla Signa GE扫描仪上完成了脑部MRI扫描。我们对ACG进行分割，并比较不同组间的左右ACG体积。在控制年龄和智商的影响的同时，评估药物对大脑中脑回体积的影响。结果：与正常组(p=0.004)和房间隔缺血组(p=0.006)相比，BD组的左侧大脑中脑回体积显著减小。右侧ACG体积无明显差异。这些差异似乎与用药或智商无关。结论：与NP儿童和被诊断为ASD的儿童相比，儿童BD患者的左侧ACG体积较小。这一研究的复制和扩展表明，ACG体积异常可能是BD的一个生物标志物。(C)2007 Elsevier B.V.保留所有权利。
Background: An increasing number of studies indicate the anterior cingulate gyrus (ACG) may play a role in the attention deficits associated with pediatric bipolar disorder (BD). Age, medications, and intelligence quotient (IQ) may affect ACG volume; few studies have controlled for these effects.Methods: We recruited 16 children with 131) and 24 children with autism spectrum disorder (ASD); 15 children with no psychiatric diagnosis (NP) were also included. All participants were evaluated with the K-SADS and a DSM-IV Autism/Asperger's Checklist; the ADI-R was also administered to ASD participants shortly after the study began. The participants completed a brain MRI scan on a 1.5Tesla Signa GE scanner. We segmented the ACG and compared left and right ACG volumes between groups. The influence of medications on the ACG volume was assessed while controlling for the effects of age and IQ.Results: The left ACG volume was significantly smaller in the BD group compared to the NP (p=0.004) and ASD (p=0.006) groups. No significant differences were found in the right ACG volume. These differences do not appear to be attributable to medication use or IQ.Conclusions: Pediatric BD patients have a smaller left ACG volume compared to NP children and children diagnosed with ASD. This replication and extension of previous studies suggest that the ACG volume abnormality may be a biomarker for BD. (C) 2007 Elsevier B.V. All rights reserved.