BIOLOGICAL EFFECTS OF SHOCK-WAVES - CAVITATION BY SHOCK-WAVES IN PIGLET LIVER
BIOLOGICAL EFFECTS OF SHOCK-WAVES - CAVITATION BY SHOCK-WAVES IN PIGLET LIVER
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DOI：
10.1016/0301-5629(90)90169-d
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发表时间：
1990-01-01
影响因子：
2.9
通讯作者：
BRENDEL, W
中科院分区：
文献类型：
--
作者：
DELIUS, M;DENK, R;BRENDEL, W
众所周知，冲击波会在体外产生空化现象。在体内，体外冲击波可能导致组织出血。当对 5 只仔猪肝脏进行体内冲击波时，通过传统的实时 B 扫描超声检测到两种类型的变化：由门静脉和肝静脉支流的肝内分支中的明亮信号组成的瞬态变化，推测源自气泡；以及由沿高压场长轴的区域变亮组成的稳态变化，推测表明该区域中充气气泡数量增加。从冲击波给药开始就出现了短暂的变化；肝血管中的明亮信号持续数百微秒，然后随血流冲走。随后出现稳态变化，在数百次冲击波后强度增加，并在停止冲击波后持续几分钟。两种类型的信号都被解释为碎石机冲击波在体内产生空化的直接证据。在碎石机桶的部分脱气水中也收到了类似的信号。对仔猪进行尸检时，在冲击波路径中检测到局灶性小叶内出血和门静脉血栓。在同一总面积内发生空化和组织损伤表明空化可能参与了冲击波引起的组织损伤的产生。
Shock waves are known to generate cavitation in vitro. In vivo, extracorpeal shock waves may cause haemorrhages in tissues. Two types of changes were detected by conventional, real-time B-scan ultrasound when shock waves were administered to 5 piglet livers in vivo: transient changes consisting of bright signals in intrahepatic branches of the portal vein and tributaries of the hepatic vein, presumed to originate from gas bubbles, and stationary changes consisting of brightening of the area along the long axis of the high pressure field, presumed to indicate an increased number of gas-filled bubbles in this area. Transient changes appeared from the start of shock wave administration; bright signals were seen in liver vessels for several hundred microseconds before they were flushed away with the blood flow. Stationary changes appeared later, increased in intensity over several hundred shock waves and persisted for minutes after cessation of shock wave administration. Both types of signals were interpreted as direct evidence that lithotripter shock waves generated cavitation in vivo. Similar signals were received in the partly degassed water of the lithotripter tub. At autopsy of the piglets, focal intralobular haemorrhages and thrombi of portal veins were detected in the shock wave path. The occurrence of cavitation and tissue damage in the same gross area suggests that cavitation might be involved in the generation of tissue damage by shock waves.