Aversive disinhibition of behavior and striatal signaling in social avoidance.
Aversive disinhibition of behavior and striatal signaling in social avoidance.
复制标题
社交回避中行为和纹状体信号的厌恶去抑制。
DOI：
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发表时间：
2014
影响因子：
4.2
通讯作者：
K. Roelofs
中科院分区：
文献类型：
--
作者：
Verena Ly;R. Cools;K. Roelofs
社交回避是导致焦虑和抑郁症状发展和维持的一个主要因素。越来越多的证据表明，社交回避与异常的厌恶加工和杏仁核信号过度活跃有关。然而，这种对行为的异常厌恶加工以及实施行为的神经机制的后果是什么还不清楚。现有的文献相互矛盾，要么加强了行动抑制，要么减少了行动抑制。我们通过比较厌恶面孔和欲望面孔对高、低社交回避个体Go/no-Go任务和相关纹状体信号的影响，考察了社交回避中厌恶和行动之间的交互作用。我们将fMRI与一种新的概率学习任务相结合，在该任务中，情绪价位(愤怒和高兴的面孔)和最佳反应(去和不去反应)是独立操纵的。与低社交回避性个体相比，高社交回避性个体对愤怒的行为抑制(不去反应的比例)相对于快乐的面孔表现出更低的抑制。这种行为去抑制与愤怒相对快乐面孔的不去反应时更大的纹状体信号相关。结果表明，在社会威胁的背景下，社交回避应对方式伴随着行为和纹状体信号的去抑制。这些发现与最近关于厌恶去抑制和情感障碍的理论是一致的。
Social avoidance is a major factor contributing to the development and maintenance of anxiety and depressive symptoms. Converging evidence suggests that social avoidance is associated with abnormal aversive processing and hyperactive amygdala signaling. However, what are the consequences of such abnormal aversive processing for action and for the neural mechanisms implementing action is unclear. Existing literature is conflicting, pointing at either enhanced or reduced action inhibition. We investigated the interaction between aversion and action in social avoidance by comparing the effects of aversive vs appetitive faces on a go/no-go task and associated striatal signals in 42 high and low socially avoidant individuals. We combined fMRI with a novel probabilistic learning task, in which emotional valence (angry and happy faces) and optimal response (go- and no-go-responses) were manipulated independently. High compared with low socially avoidant individuals showed reduced behavioral inhibition (proportion no-go-responses) for angry relative to happy faces. This behavioral disinhibition correlated with greater striatal signal during no-go-responses for angry relative to happy faces. The results suggest that social avoidant coping style is accompanied by disinhibition of action and striatal signal in the context of social threat. The findings concur with recent theorizing about aversive disinhibition and affective disorders.
影响因子：
6.6
作者：
KESSLER, RC;MCGONAGLE, KA;NELSON, CB
通讯作者：
NELSON, CB
DOI：
10.1037/0097-7403.30.2.104
发表时间：
2004-04-01
期刊：
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIORAL PROCESSES
影响因子：
--
作者：
Holland, PC
通讯作者：
Holland, PC