Adipose Tissue Inflammation Induces B Cell Inflammation and Decreases B Cell Function in Aging.
Adipose Tissue Inflammation Induces B Cell Inflammation and Decreases B Cell Function in Aging.
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DOI：
10.3389/fimmu.2017.01003
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发表时间：
2017
影响因子：
7.3
通讯作者：
Blomberg BB
中科院分区：
文献类型：
--
作者：
Frasca D;Blomberg BB
衰老是患慢性病的最大危险因素。炎症老化，与年龄相关的低度慢性炎症增加，可能是与年龄相关的疾病中的一个常见环节。这篇综述总结了最近发表的关于与年龄相关的炎症增加的潜在细胞和分子机制的数据，以及这些机制如何有助于老年小鼠和人类体液免疫应答的降低。简单地说，我们涵盖了衰老和相关炎症如何降低小鼠和人类的抗体反应，以及肥胖如何通过增加炎症促进衰老机制。我们还报告了文献中的数据，显示脂肪组织浸润免疫细胞，以及这些细胞如何被招募并导致局部和全身炎症。我们发现，几种类型的免疫细胞浸润的脂肪组织，这些细胞包括巨噬细胞，中性粒细胞，NK细胞，先天性淋巴细胞，嗜酸性粒细胞，T细胞，B1和B2细胞。我们的主要焦点是脂肪组织如何影响免疫反应，特别是B细胞反应和抗体产生。瘦素在产生炎症和降低B细胞反应中的作用也进行了讨论。我们报告了我们和其他小组发表的数据，显示脂肪组织产生促炎性B细胞亚群，其诱导促炎性T细胞，促进胰岛素抵抗，并分泌致病性自身免疫抗体。
Aging is the greatest risk factor for developing chronic diseases. Inflamm-aging, the age-related increase in low-grade chronic inflammation, may be a common link in age-related diseases. This review summarizes recent published data on potential cellular and molecular mechanisms of the age-related increase in inflammation, and how these contribute to decreased humoral immune responses in aged mice and humans. Briefly, we cover how aging and related inflammation decrease antibody responses in mice and humans, and how obesity contributes to the mechanisms for aging through increased inflammation. We also report data in the literature showing adipose tissue infiltration with immune cells and how these cells are recruited and contribute to local and systemic inflammation. We show that several types of immune cells infiltrate the adipose tissue and these include macrophages, neutrophils, NK cells, innate lymphoid cells, eosinophils, T cells, B1, and B2 cells. Our main focus is how the adipose tissue affects immune responses, in particular B cell responses and antibody production. The role of leptin in generating inflammation and decreased B cell responses is also discussed. We report data published by us and by other groups showing that the adipose tissue generates pro-inflammatory B cell subsets which induce pro-inflammatory T cells, promote insulin resistance, and secrete pathogenic autoimmune antibodies.
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DOI：
10.4049/jimmunol.1003964
发表时间：
2012-01-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Frasca D;Romero M;Diaz A;Alter-Wolf S;Ratliff M;Landin AM;Riley RL;Blomberg BB
通讯作者：
Blomberg BB
影响因子：
9.1
作者：
Agrawal, Sudhanshu;Gupta, Sudhir
通讯作者：
Gupta, Sudhir
影响因子：
7.8
作者：
Duggal NA;Upton J;Phillips AC;Sapey E;Lord JM
通讯作者：
Lord JM
DOI：
10.1186/1742-4933-10-3
发表时间：
2013-01-23
期刊：
Immunity & ageing : I & A
影响因子：
--
作者：
Gupta S;Agrawal S;Gollapudi S
通讯作者：
Gollapudi S
DOI：
10.1073/pnas.1215840110
发表时间：
2013-03-26
影响因子：
11.1
作者：
DeFuria, Jason;Belkina, Anna C.;Nikolajczyk, Barbara S.
通讯作者：
Nikolajczyk, Barbara S.