Characterization of self-organized TiO2 nanotubes on Ti-4Zr-22Nb-2Sn alloys and the application in drug delivery system
Characterization of self-organized TiO2 nanotubes on Ti-4Zr-22Nb-2Sn alloys and the application in drug delivery system
复制标题
Ti-4Zr-22Nb-2Sn合金上自组织TiO2纳米管的表征及其在药物输送系统中的应用
DOI：
10.1007/s10856-011-4234-6
复制
发表时间：
2011-03-01
影响因子：
3.7
通讯作者：
Yang, X. J.
中科院分区：
文献类型：
--
作者：
Liang, Y. Q.;Cui, Z. D.;Yang, X. J.
本研究以Ti-4 Zr-22 Nb-2Sn为原料，在不同电位、NH 4F浓度和阳极氧化时间下，通过阳极氧化法制备了自组织TiO 2纳米管。用FE-SEM观察了纳米管的形貌。载药纳米管也在含有盐酸米诺环素的水介质中制备。通过SEM、XPS、FT-IR等手段对纳米管进行了表征，结果表明，盐酸米诺环素（MH）被负载在纳米管中。在磷酸盐缓冲溶液（PBS）中研究了释放效果。在PBS溶液中，较短管长的TiO 2纳米管的MH释放速率低于较长管的MH释放速率。缓释时间可达150 h以上。因此，在钛合金作为生物医用植入物时，通过管道载药来消除有害反应是一种很有前途的方法。
In this study, the self-organized TiO2 nanotubes grown by anodization of Ti-4Zr-22Nb-2Sn at different potentials, concentration of NH4F and anodization time was investigated. The morphology of nanotubes was observed by FE-SEM. The drug-loaded nanotubes were also fabricated in aqueous media containing minocycline hydrochloride. They were characterized by SEM, XPS and FT-IR. The results showed that the drug of minocycline hydrochloride (MH) was loaded in the nanotubes. The release effects were studied in phosphate buffer solution (PBS). The release rate of MH from TiO2 nanotubes with shorter tube length in PBS was lower than the one of MH from longer nanotubes. The sustaining release time could last at least 150 h. Hence, it is a promising method to eliminate the harmful reactions by carrying drug in the tubes when the titanium alloys were used as biomedical implants.