A COMPARISON BETWEEN 6-POINT DIXON MRI AND MR SPECTROSCOPY TO QUANTIFY MUSCLE FAT IN THE THIGH OF SUBJECTS WITH SARCOPENIA
A COMPARISON BETWEEN 6-POINT DIXON MRI AND MR SPECTROSCOPY TO QUANTIFY MUSCLE FAT IN THE THIGH OF SUBJECTS WITH SARCOPENIA
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DOI：
10.14283/jfa.2018.16
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发表时间：
2019-01-01
影响因子：
3.9
通讯作者：
Quick, H. H.
中科院分区：
文献类型：
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作者：
Grimm, A.;Meyer, H.;Quick, H. H.
背景：肌肉脂肪组成的变化，例如在肌肉减少症中观察到的变化，会影响身体表现和肌肉功能，如力量和力量。目的：本研究的目的是比较6点迪克森磁共振成像和多回波磁共振波谱序列定量肌肉脂肪。环境、参与者和测量：招募两组（G1: 23名健康年轻男性（28 +/- 4岁），G2: 56名肌肉减少症男性（80 +/- 5岁））。采用左大腿肌肉的6点积和6点原型Dixon序列，以及左大腿半腱肌内的高速多回声T2*校正H1磁共振波谱序列测量质子密度脂肪分数。为了评价不同方法之间的可比性，对质子密度脂肪分数结果进行了Bland-Altman和线性回归分析。结果：光谱学和6pt Dixon序列的平均差值+/- 1.96 *标准差分别为1.9 +/- 3.3%和1.5 +/- 3.6%。6点Dixon序列的质子密度脂肪分数结果与光谱学之间存在较高的相关性（产品序列R = 0.95，原型序列R = 0.97）。结论：Dixon成像和光谱序列对大腿脂肪测量显示出相当的准确性。光谱学是一种局部测量，而迪克森序列提供了脂肪分布图。6点Dixon序列与光谱学的高度相关性支持其临床应用。它们提供比光谱更高的空间分辨率，但不适合更复杂的光谱分析，以分离细胞外和细胞内的脂质。
Background: Changes in muscle fat composition as for example observed in sarcopenia, affect physical performance and muscular function, like strength and power. Objectives: The purpose of this study was to compare 6-point Dixon magnetic resonance imaging and multi-echo magnetic resonance spectroscopy sequences to quantify muscle fat. Setting, participants and measurements: Two groups were recruited (G1: 23 healthy young men (28 +/- 4 years), G2: 56 men with sarcopenia (80 +/- 5 years)). Proton density fat fraction was measured with a 6-point product and a 6-point prototype Dixon sequence in the left thigh muscle and with a highspeed multi-echo T2*-corrected H1 magnetic resonance spectroscopy sequence within the semitendinosus muscle of the left thigh. To evaluate the comparability among the different methods, Bland-Altman and linear regression analyses of the proton density fat fraction results were performed. Results: Mean differences +/- 1.96 * standard deviation between spectroscopy and 6pt Dixon sequences were 1.9 +/- 3.3% and 1.5 +/- 3.6% for the product and prototype sequences, respectively. High correlations were measured between the proton density fat fraction results of the 6-point Dixon sequences and spectroscopy (R = 0.95 for the product sequence and R = 0.97 for the prototype sequence). Conclusions: Dixon imaging and spectroscopy sequences show comparable accuracy for fat measurements in the thigh. Spectroscopy is a local measurement, whereas Dixon sequences provide maps of the fat distribution. The high correlations of the 6-point Dixon sequences with spectroscopy support their clinical use. They provide higher spatial resolution than spectroscopy, but are not suitable for a more complicated spectral analysis to separate extra-and intramyocellular lipids.