Microfluidic Platform for the Continuous Production and Characterization of Multilamellar Vesicles: A Synchrotron Small-Angle X-ray Scattering (SAXS) Study
Microfluidic Platform for the Continuous Production and Characterization of Multilamellar Vesicles: A Synchrotron Small-Angle X-ray Scattering (SAXS) Study
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DOI：
10.1021/acs.jpclett.6b02468
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发表时间：
2017-01-05
影响因子：
5.7
通讯作者：
Yaghmur, Anan
中科院分区：
文献类型：
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作者：
Ghazal, Aghiad;Gontsarik, Mark;Yaghmur, Anan
利用同步辐射小角X射线散射（SAXS）结合微流控平台监测多层囊泡（MLV）的连续生产。它们的产生是快速的，并且在脂质和水相之间的接触的小于0.43秒内开始演变。为了获得具有窄尺寸分布的纳米颗粒，重要的是使用具有比通常用于SAXS实验的微通道更窄的微通道的改进的流体动力学流动聚焦（HFF）微流体装置。实现了尺寸小至160 nm的单分散MLV，多分散指数（PDI）约为0.15。所产生的纳米颗粒更小，并且具有比通过常规本体混合方法获得的那些更窄的尺寸分布。因此，这种微流体平台具有连续生产单分散NP的巨大潜力。
A microfluidic platform combined with synchrotron small-angle X-ray scattering (SAXS) was used for monitoring the continuous production of multilamellar vesicles (MLVs). Their production was fast and started to evolve within less than 0.43 s of contact between the lipids and the aqueous phase. To obtain nanoparticles with a narrow size distribution, it was important to use a modified hydrodynamic flow focusing (HFF) microfluidic device with narrower microchannels than those normally used for SAXS experiments. Monodispersed MLVs as small as 160 nm in size, with a polydispersity index (PDI) of approximately 0.15 were achieved. The nanoparticles produced were smaller and had a narrower size distribution than those obtained via conventional bulk mixing methods. This microfluidic platform therefore has a great potential for the continuous production of monodispersed NPs.