The emerging role of miR-506 in cancer.
The emerging role of miR-506 in cancer.
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miR-506 在癌症中的新作用
DOI：
10.18632/oncotarget.11294
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发表时间：
2016-09-20
期刊：
影响因子：
--
通讯作者：
Wang H
中科院分区：
文献类型：
--
作者：
Li J;Ju J;Ni B;Wang H
MicroRNAs （miRNAs）是一种小的非编码rna，在转录后调控基因表达。它们几乎参与了所有的生物过程，其中许多已被确定为潜在的致癌基因或肿瘤抑制基因。最近发现miR-506在调节细胞增殖、分化、迁移和侵袭中起关键作用。miR-506的失调已在多种类型的癌症中得到证实；然而，它是作为致癌基因还是肿瘤抑制基因似乎与环境有关。miR-506在癌症中的表达改变是由启动子甲基化和上游转录因子的改变引起的。在这篇综述中，我们总结了目前对miR-506的多种作用和潜在机制及其在癌症中的参与的理解，并提出了基于miR-506的潜在治疗策略。
MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression. They are involved in almost all biological processes, and many have been identified as potential oncogenes or tumor suppressor genes. miR-506 was recently discovered to play pivotal roles in regulating cell proliferation, differentiation, migration and invasion. Dysregulation of miR-506 has been demonstrated in multiple types of cancers; however, whether it functions as an oncogene or a tumor suppressor seems to be context-dependent. Altered miR-506 expression in cancer is caused by promoter methylation and changes in upstream transcription factors. In this review, we summarize the current understanding of the diverse roles and underlying mechanisms of miR-506 and its involvement in cancer, and suggest the potential therapeutic strategy based on miR-506.