SLEEP SPINDLE AND DELTA CHANGES DURING CHRONIC USE OF A SHORT-ACTING AND A LONG-ACTING BENZODIAZEPINE HYPNOTIC
SLEEP SPINDLE AND DELTA CHANGES DURING CHRONIC USE OF A SHORT-ACTING AND A LONG-ACTING BENZODIAZEPINE HYPNOTIC
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DOI：
10.1016/0013-4694(83)90276-6
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发表时间：
1983-01-01
期刊：
影响因子：
--
通讯作者：
DEMENT, WC
中科院分区：
文献类型：
--
作者：
JOHNSON, LC;SPINWEBER, CL;DEMENT, WC
在一项双盲、平行小组设计研究中，对经过医学筛查的失眠症患者 (21) 进行了为期 59 个晚上的研究。接受短效（三唑仑）的 7 名患者和接受长效（氟西泮）苯二氮卓类安眠药的 7 名患者显示出相似的睡眠 EEG（脑电图）变化模式和幅度，特别是在 37 晚治疗期间的后半段。两组均显着增加了睡眠纺锤率并减少了每分钟的增量计数。戒断模式也相似。 N-去烷基氟西泮的血浆水平与脑电图变化的程度没有显着相关。
Medically screened insomniacs (21) were studied over 59 nights in a double-blind, parallel groups design study. The 7 patients receiving a short-acting (triazolam) and the 7 receiving a long-acting (flurazepam) benzodiazepine hypnotic showed a similar pattern and magnitude of sleep EEG [electoencephalogram] changes, especially during the latter part of the 37-night treatment period. Both groups significantly increased sleep spindle rate and decreased delta count per min. The patterns of withdrawal were also similar. Plasma levels of N-desalkylflurazepam were not significantly related to the magnitude of EEG changes.