Assessing degeneration of human articular cartilage with ultra-short echo time (UTE) T2* mapping.
Assessing degeneration of human articular cartilage with ultra-short echo time (UTE) T2* mapping.
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DOI：
10.1016/j.joca.2010.02.001
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发表时间：
2010-04
影响因子：
7
通讯作者：
Chu, C. R.
中科院分区：
文献类型：
--
作者：
Williams, A.;Qian, Y.;Bear, D.;Chu, C. R.
研究超短回波时间（UTE）T2* 标测对人关节软骨胶原基质变性的敏感性。在4个人胫骨平台取出物上采集MRI UTE-T2* 图和标准T2图。收集33个骨软骨核心进行偏振光显微镜（PLM）和成分分析。从PLM和组织学图像评价胶原基质完整性。在空间配准的基础上，将基质完整性和组成与标准T2值和UTE-T2* 值进行比较。UTE-T2* 值随基质变性而变化（p=0.008），与健康组织相比，严重退化软骨中的UTE-T2* 值较低（p=0.012）。检测到健康组织中UTE-T2* 值高于轻度退化组织的趋势（p=0.051）。未发现标准T2值随基质退化而变化（p=0.13），但与健康组织相比，严重退化软骨中的标准T2值往往更高。UTE-T2* 值变化与II型胶原和糖胺聚糖含量无关。邻近软骨下骨的深层软骨的UTE-T2* 标测比该区的标准T2标测更稳健。关节软骨的UTE-T2* 映射对基质变性敏感，并检测短T2信号，特别是在深层组织中，这不能很好地被标准T2映射捕获。UTE-T2* 值和PLM指数的相关性支持两者可能对胶原微结构敏感的假设。进一步探索UTE-T2* 映射作为一种非侵入性的工具，以检测早期关节软骨退变是必要的。
To examine the sensitivity of ultra-short echo time (UTE) T2* mapping to collagen matrix degeneration in human articular cartilage. MRI UTE-T2* maps and standard T2 maps were acquired on four human tibial plateau explants. Thirty-three osteochondral cores were harvested for polarized light microscopy (PLM), and composition analyses. Collagen matrix integrity was evaluated from PLM and histological images. Matrix integrity and composition was compared to standard T2 values and UTE-T2* values on a spatially registered basis. UTE-T2* values varied with matrix degeneration (p=0.008) and were lower in severely degraded cartilage compared to healthy tissue (p=0.012). A trend for higher UTE-T2* values in healthy tissue compared to mildly degenerate tissue (p=0.051) was detected. Standard T2 values were not found to vary with matrix degeneration (p=0.13) but tended to be higher in severely degraded cartilage compared to healthy tissue. UTE-T2* value variations were independent of type II collagen and glycosaminoglycan contents. UTE-T2* mapping of deep cartilage, adjacent to subchondral bone, was more robust than standard T2 mapping in this zone. UTE-T2* mapping of articular cartilage is sensitive to matrix degeneration and detects short T2 signal, particularly in deep tissue, that is not well captured by standard T2 mapping. Correlation of UTE-T2* values and PLM indices supports the hypothesis that both may be sensitive to collagen microstructure. Further exploration of UTE-T2* mapping as a noninvasive tool to detect early articular cartilage degeneration is warranted.
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