Evaluation of Endometrial Precancerous Lesions in Postmenopausal Obese Women - A High Risk Group?
Evaluation of Endometrial Precancerous Lesions in Postmenopausal Obese Women - A High Risk Group?
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DOI：
10.7314/apjcp.2014.15.1.195
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发表时间：
2014-01-01
影响因子：
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通讯作者：
Unal, Dilek
中科院分区：
文献类型：
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作者：
Acmaz, Gokhan;Aksoy, Huseyin;Unal, Dilek
目的：探讨绝经后肥胖妇女子宫内膜增生、息肉等癌前病变的发生情况。材料与方法：对绝经后子宫异常出血或宫颈细胞学检查发现子宫内膜细胞的妇女进行调查。比较了癌前病变（增生和子宫内膜息肉）组和病理正常组之间的人体测量，如身高，体重，体重指数，腰/臀比和子宫内膜厚度。结果：我们检测到有癌前病变患者的子宫内膜增厚，具有统计学意义。癌前病变患者的体重指数高于病理正常组。结论：我们发现绝经后超重和肥胖妇女的癌前病变率升高，考虑到世界大部分地区肥胖的患病率正在增加，这一点很有意义。虽然子宫内膜癌的筛查不推荐给一般人群，但在肥胖绝经后妇女等高危人群中，它可能非常重要。
Aim: To evaluate precancerous lesions such as hyperplasia and endometrial polyps in obese postmenopausal women. Materials and Methods: Women who were referred with abnormal uterine bleeding in postmenopausal period or the presence of endometrial cells on cervical cytology in our department were investigated. Anthropometric measurements such as height, weight, body mass index, waist/hip ratio and endometrial thickness were compared between a precancerous lesion (hyperplasia and endometrial polyp) group and a pathologically normal group. Results: We detected statistically significant thickening of endometrium in patients with precancerous lesions. Moreover patients with precancerous lesions had higher body mass index than the pathologically normal group. Conclusions: We found elevated precancerous lesion rates in overweight and obese women in the postmenopausal period, of interest given that the prevalence of obesity is increasing in most parts of the world. Although screening for endometrial cancer is not recommended for the general population, in high-risk populations like obese postmenopausal women, it may be very important.