Polymorphisms in genes related to bacterial lipopolysaccharide/peptidoglycan signaling and gastric precancerous lesions in a population at high risk for gastric cancer
Polymorphisms in genes related to bacterial lipopolysaccharide/peptidoglycan signaling and gastric precancerous lesions in a population at high risk for gastric cancer
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DOI：
10.1007/s10620-006-9303-1
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发表时间：
2007-01-01
影响因子：
3.1
通讯作者：
Munoz, Nubia
中科院分区：
文献类型：
--
作者：
Kato, Ikuko;Canzian, Federico;Munoz, Nubia
由于幽门螺杆菌（HP）是一种革兰氏阴性菌，我们研究了委内瑞拉人群中涉及脂多糖（LPS）信号传导的基因的几种功能多态性与不同阶段胃癌前病变患病率之间的关系。两个NOD2多态性del3020insC和Gly908Arg太少见，无法研究它们与胃病变的关系。携带CD14 T-260等位基因的受试者发生肠化生（IM）的风险明显高于不携带该等位基因的受试者。在该等位基因的纯合子中观察到类似但不显著的发育不良风险增加。TLR4 Asp299Gly多态性与任何类型的病变均无相关性，除了在HP组织学评分较高的受试者中，AA基因型相关的IM风险略有不显著增加。这些结果表明，HP LPS信号的遗传多态性可能与胃癌前病变的中期发展有关。
As Helicobacter pylori (HP) is a Gram-negative bacterium, we investigated the associations between several functional polymorphisms in genes involved in lipopolysaccharide (LPS) signaling and the prevalence of various stages of gastric premalignant lesions in a Venezuelan population. The two NOD2 polymorphisms, del3020insC and Gly908Arg, were too infrequent to study their associations with gastric lesions. The risk of intestinal metaplasia (IM) was significantly increased among subjects with the CD14 T-260 allele compared to those without this allele. A similar, but nonsignificant increase in risk for dysplasia was observed among homozygotes of this allele. There was no association between TLR4 Asp299Gly polymorphism and any type of lesions, except for a slight nonsignificant increase in risk of IM associated with the AA genotype among subjects with a higher histological HP score. These results suggest that genetic polymorphisms in HP LPS signaling may be implicated in the development of intermediate stages of gastric premalignant lesions.