A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome
A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome
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DOI：
10.1126/science.1069193
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发表时间：
2002-05-31
期刊：
影响因子：
56.9
通讯作者：
Venter, JC
中科院分区：
文献类型：
--
作者：
Mural, RJ;Adams, MD;Venter, JC
通过对小鼠16号染色体（Mmu 16）序列的分析，证明了小鼠和人类基因组之间的高度相似性，该序列是作为小鼠基因组全基因组霰弹枪组装的一部分获得的。由于重复DNA含量较低，小鼠基因组比人类基因组小10%左右。将Mmu 16与人类基因组同源片段的结构和蛋白质编码潜力进行比较，确定了与人类染色体（Hsa） 3、8、12、16、21和22的保守同源区域。基因的含量和顺序在Mmu 16和人类基因组的合成块之间高度保守。在Mmu 16上的731个预测基因中，509个与人类基因组相应部分的同源基因一致，44个可能与这些基因相似，164个基因在人类基因组的其他地方有同源基因；有14种基因在人类中找不到对应的基因。
The high degree of similarity between the mouse and human genomes is demonstrated through analysis of the sequence of mouse chromosome 16 (Mmu 16), which was obtained as part of a whole-genome shotgun assembly of the mouse genome. The mouse genome is about 10% smaller than the human genome, owing to a lower repetitive DNA content. Comparison of the structure and protein-coding potential of Mmu 16 with that of the homologous segments of the human genome identifies regions of conserved synteny with human chromosomes (Hsa) 3, 8, 12, 16, 21, and 22. Gene content and order are highly conserved between Mmu 16 and the syntenic blocks of the human genome. Of the 731 predicted genes on Mmu 16, 509 align with orthologs on the corresponding portions of the human genome, 44 are likely paralogous to these genes, and 164 genes have homologs elsewhere in the human genome; there are 14 genes for which we could find no human counterpart.