ASSOCIATION OF HIGH PLASMA PRORENIN WITH DIABETIC-RETINOPATHY
ASSOCIATION OF HIGH PLASMA PRORENIN WITH DIABETIC-RETINOPATHY
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DOI：
10.1097/00004872-198812040-00145
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发表时间：
1988-12-01
影响因子：
4.9
通讯作者：
DEJONG, PTVM
中科院分区：
文献类型：
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作者：
FRANKEN, AAM;DERKX, FHM;DEJONG, PTVM
长期糖尿病患者血浆原肾素升高，而非肾素升高。肾脏病和自主神经病变被认为是病因。然而，我们发现，尽管高水平的循环前肾素和一个非常低的肾血浆流量，在5例糖尿病合并终末期肾病和增殖性糖尿病视网膜病变的患者中，整个肾脏的前肾素没有动静脉差异。16例非糖尿病自主神经病变患者血浆肾素原正常。在223例连续患者中，高水平的前肾素的存在与糖尿病视网膜病变的存在密切相关，特别是增殖型。这种关联与胰岛素需求、代谢控制和肾病或神经病变的存在无关。这些数据表明，糖尿病患者血浆肾素原升高的一部分是由肾外来源产生的，并且可能受糖尿病视网膜病变影响的眼睛是该来源。
Plasma prorenin, but not renin, is elevated in long-standing diabetes mellitus. Nephropathy and autonomic neuropathy have been implicated as causes. However, we found no arteriovenous difference in prorenin across the kidney, despite high levels of circulating prorenin and a very low renal plasma flow, in five diabetics with combined end-stage nephropathy and proliferative diabetic retinopathy. Moreover, plasma prorenin was normal in 16 non-diabetics with autonomic neuropathy. The presence of a high level of prorenin was closely associated with the presence of diabetic retinopathy, particularly the proliferative type, in 223 consecutive patients. This association was independent of insulin requirements, metabolic control and of the presence of nephropathy or neuropathy. These data are evidence that part of the elevated plasma prorenin in diabetics is produced by an extrarenal source and that perhaps the eye affected by diabetic retinopathy is that source.