Maternal alcohol abuse and neonatal infection
Maternal alcohol abuse and neonatal infection
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DOI：
10.1097/01.alc.0000167956.28160.5e
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发表时间：
2005-06-01
影响因子：
3.2
通讯作者：
Brown, LAS
中科院分区：
文献类型：
--
作者：
Gauthier, TW;Drews-Botsch, C;Brown, LAS
背景：由于长期饮酒会抑制成人免疫系统，我们检验了母体饮酒会增加足月新生儿感染风险的假设。*方法：对出生体重与胎龄的大型病例对照研究进行分析，重点关注妊娠期>= 36周的足月新生儿的母亲酒精摄入与感染的发展。分娩后，母亲被问及怀孕前3个月、妊娠1(1)、2(2)和3(3)个月的酒精和烟草使用情况。结果：共发现872例妊娠36周的单胎新生儿（872例）进行分析。新生儿感染51例（5.8%）。感染和未感染新生儿的胎龄、性别和小胎龄（SGA）相似（p = NS）。母亲报告在怀孕期间饮酒、过度饮酒或吸烟的婴儿，其新生儿被诊断为感染的可能性高于报告不饮酒或不吸烟的母亲（p < 0.05）。当控制种族和吸烟时，母亲饮酒的SGA婴儿感染风险增加2.5倍，而过度饮酒使风险增加3-4倍。在一项多变量logistic回归分析中，控制了低母亲收入、吸烟和SGA，妊娠2(2)个月过度饮酒增加了新生儿感染的风险（OR 3.7 [1.1,12.8], p < 0.05）。结论：在该患者样本中，产妇过度饮酒与新生儿感染风险增加有关。提高认识和进一步的临床研究是必要的，以解决胎儿酒精暴露对发育中的免疫系统的有害影响。关键词：胎儿酒精，感染，新生儿。
Background: Since chronic alcohol use suppresses the adult immune system, we tested the hypothesis that maternal alcohol ingestion increases the risk of infection in term newborns.*Methods: Analysis of a large case-control study of birth weight for gestational age was performed focusing on maternal alcohol ingestion and the development of infection in term newborns >= 36 weeks gestation. After delivery, mothers were asked about alcohol and tobacco use in the 3 months prior to conception, the 1(st), 2(nd), and 3(rd) trimester of pregnancy.Results: Eight hundred and seventy-two singleton newborns (872) 36 weeks gestation were identified for analysis. A total of 51 (5.8%) had newborn infections. Gestational age, sex, and small for gestational age (SGA) were similar in the newborns with and without infection (p = NS). Infants whose mothers reported alcohol use, excessive drinking or smoking in pregnancy were more likely to have a newborn diagnosed with an infection than were mothers who reported abstaining from alcohol or cigarettes (p < 0.05). When controlling for race and smoking, SGA infants whose mothers used any alcohol had a 2.5-fold increase risk of infection, while excessive alcohol use increased the risk 3-4-fold. In a multivariable logistic regression analysis controlling for low maternal income, smoking, and SGA, excessive alcohol use during the 2(nd) trimester increased the risk of newborn infection (OR 3.7 [1.1,12.8], p < 0.05).Conclusions: Excessive maternal alcohol use is associated with an increased risk of newborn infection in this patient sample. Increased awareness and further clinical investigations are warranted to address the detrimental effects of fetal alcohol exposure on the developing immune system. Key Words: Fetal Alcohol, Infection, Newborn.