Reduced expression of glyoxalase-1 mRNA in mood disorder patients
Reduced expression of glyoxalase-1 mRNA in mood disorder patients
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DOI：
10.1016/j.neulet.2008.04.024
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发表时间：
2008-06-20
影响因子：
2.5
通讯作者：
Watanabe, Yoshifumi
中科院分区：
文献类型：
--
作者：
Fujimoto, Michiko;Uchida, Shusaku;Watanabe, Yoshifumi
Glycoproteinase-1（Glo 1）是一种抗氧化酶，其使α-酮醛解毒以防止促氧化剂化合物（如甲基乙二醛）在所有细胞类型中的积累。Glo 1被认为与焦虑症、自闭症和阿尔茨海默病有关。心境障碍与焦虑障碍的共病率很高，尽管迄今为止，Glo 1在这些疾病的病理生理学中的参与知之甚少。本研究通过检测心境障碍患者外周血白色细胞中Glo 1 mRNA的表达水平，探讨Glo 1在心境障碍中的作用。定量实时聚合酶链反应实验表明，Glo 1 mRNA的表达减少，观察在抑郁症和双相情感障碍患者在当前的抑郁状态，与健康对照组相比。相比之下，与健康对照受试者相比，处于缓解状态的重性抑郁症和双相情感障碍患者的Glo 1 mRNA表达没有显着变化。这些结果表明Glo 1的异常表达可能参与了心境障碍的病理生理过程。(C)2008爱思唯尔爱尔兰有限公司保留所有权利。
Glyoxalase-1 (Glo1) is an antioxidant enzyme which detoxifies alpha-ketoaldehydes to prevent the accumulation of pro-oxidant compounds, such as methylglyoxal, in all cell types. Glo1 has been suggested to be involved in anxiety disorders, autism, and Alzheimer's disease. Mood disorders have a high rate of comorbidity with anxiety disorders although, to date, little is known of the involvement of Glo1 in the pathophysiology of these conditions. In the present study, we examined the expression levels of Glo1 mRNA in peripheral white blood cells of mood disorder patients to understand the role of Glo1 in mood disorders. Quantitative real-time polymerase chain reaction experiments revealed that reduced expression of Glo1 mRNA was observed in major depressive and bipolar disorder patients in a current depressive state, as compared with healthy control subjects. In contrast, the expression of Glo1 mRNA in major depressive and bipolar patients, in a remissive state, showed no significant alteration when compared with healthy control subjects. These results suggest that the aberrant expression of Glo1 might be involved in the pathophysiology of mood disorders. (C) 2008 Elsevier Ireland Ltd. All rights reserved.