Gene3D: expanding the utility of domain assignments.
Gene3D: expanding the utility of domain assignments.
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DOI：
10.1093/nar/gkv1231
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发表时间：
2016-01-04
影响因子：
14.9
通讯作者：
Lees JG
中科院分区：
文献类型：
--
作者：
Lam SD;Dawson NL;Das S;Sillitoe I;Ashford P;Lee D;Lehtinen S;Orengo CA;Lees JG
Gene3d http://gene3d.biochem.ucl.ac.uk是eNsembl和uniprotkb蛋白序列的域注释的数据库。 NAR和在这里报告了网站和数据库的更新。自上次出版物以来，我们的蛋白质序列数量增加了一倍以上。此外，结构模型已经扩展到包括额外的模型生物（果蝇杂物）。基因3D网站中的可视化工具。
Gene3D http://gene3d.biochem.ucl.ac.uk is a database of domain annotations of Ensembl and UniProtKB protein sequences. Domains are predicted using a library of profile HMMs representing 2737 CATH superfamilies. Gene3D has previously featured in the Database issue of NAR and here we report updates to the website and database. The current Gene3D (v14) release has expanded its domain assignments to ∼20 000 cellular genomes and over 43 million unique protein sequences, more than doubling the number of protein sequences since our last publication. Amongst other updates, we have improved our Functional Family annotation method. We have also improved the quality and coverage of our 3D homology modelling pipeline of predicted CATH domains. Additionally, the structural models have been expanded to include an extra model organism (Drosophila melanogaster). We also document a number of additional visualization tools in the Gene3D website.