Decreased nonlinear complexity and chaos during sleep in first episode schizophrenia: a preliminary report
Decreased nonlinear complexity and chaos during sleep in first episode schizophrenia: a preliminary report
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DOI：
10.1016/j.schres.2004.02.015
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发表时间：
2004-12-01
影响因子：
4.5
通讯作者：
Yeragani, VK
中科院分区：
文献类型：
--
作者：
Keshavan, MS;Cashmere, JD;Yeragani, VK
精神分裂症的特征是睡眠结构紊乱。人们认为睡眠异常可能是与这种疾病相关的信息处理缺陷的基础。睡眠数据的非线性分析可以提供关于可能与睡眠功能相关的睡眠特征的有价值的信息。本研究探讨的可预测性和非线性复杂性的睡眠EEG时间序列在两个EEG通道（C4和174）使用非线性措施，如符号动力学和最大李雅普诺夫指数（LLE）在精神分裂症。对一系列首次发作的精神分裂症或情感性精神障碍患者和年龄匹配的健康对照者在清醒期、1/2期、慢波睡眠（3/4期）和快速眼动（REM）睡眠中进行了研究。与对照组相比，患者在清醒阶段的非线性评分显著降低，这表明清醒EEG发生的各种参数之间的相互作用可能减少。符号动力学和LLE显着降低患者在REM与健康对照组相比，这表明降低非线性复杂性的EEG时间序列和减少混乱的精神分裂症。通过威斯康星州卡片分类测试评估，非线性复杂性降低也与神经认知缺陷相关。精神分裂症患者清醒和REM睡眠期间EEG时间序列的复杂性降低可能是精神障碍（如精神分裂症）处理信息能力受损的基础。(C)2004 Elsevier B. V.保留所有权利。
Schizophrenia is characterized by disturbed sleep architecture. It has been thought that sleep abnormalities may underlie information processing deficits associated with this disorder. Nonlinear analyses of sleep data can provide valuable information on sleep characteristics that may be relevant to the functions of sleep. This study examined the predictability and nonlinear complexity of sleep EEG time series in two EEG channels (C4 and 174) using measures of nonlinearity, such as symbolic dynamics and the largest Lyapunov exponent (LLE) in schizophrenia. A series of antipsychotic naive patients with first episode of schizophrenia or schizoaffective disorder and age-matched healthy controls were studied during awake period, stage 1/2, slow wave sleep (stage 3/4) and rapid eye movement (REM) sleep. Nonlinearity scores were significantly lower during awake stage in patients compared to controls suggesting that there may be a diminished interplay between various parameters for the genesis of waking EEG. Symbolic dynamics and LLE were significantly lower in patients during REM compared to healthy controls, suggesting decreased nonlinear complexity of the EEG time series and diminished chaos in schizophrenia. Decreased nonlinear complexity was also correlated with neurocognitive deficits as assessed by the Wisconsin card sorting test. Diminished complexity of EEG time series during awake and REM sleep in patients with schizophrenia may underlie the impaired ability to process information in psychotic disorders such as schizophrenia. (C) 2004 Elsevier B.V. All rights reserved.