SERUM TRACE-ELEMENTS IN CHILDREN RECEIVING LONG-TERM PARENTERAL-NUTRITION
SERUM TRACE-ELEMENTS IN CHILDREN RECEIVING LONG-TERM PARENTERAL-NUTRITION
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DOI：
10.1016/s0022-3476(86)80225-6
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发表时间：
1986-10-01
影响因子：
5.1
通讯作者：
MEURLING, S
中科院分区：
文献类型：
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作者：
DAHLSTROM, KA;AMENT, ME;MEURLING, S
本文测定了18例4 ~ 65个月长期接受全肠外营养（IPN）的儿童血清中微量元素铁（Fe）、铜（Cu）、锌（Zn）、硒（Se）、铬（Cr）、锰（Mn）、镍（Ni）、铷（Rb）和溴（Br）。9名患者（第1组）接受TPN作为其唯一的营养来源;其他9名患者（第2组）摄入其总热量需求的30%至70%，其余患者接受静脉注射。对照组由19名年龄和性别分布相似的健康儿童组成。第1组和第2组接受肠外营养28.4 ±。13.7（SD）和23.1 .+-。17.1（SD）个月。第1组的所有患者和第2组的4名患者均患有短肠综合征;第2组的4名患者患有假性梗阻综合征。第1组患者的血清Fe、Cu和Mn水平正常，但Zn水平升高; Se、Cr、Ni、Rb和Br的血清浓度降低。第2组患者血清Mn、Cr、Ni、Rb和Br水平降低。接受TPN的儿童中未补充TPN溶液中的微量元素（Se、Cr、Mn、Ni、Rb和Br）低于对照儿童，表明这些微量元素从食物和TPN溶液中摄入不足。然而，没有观察到微量元素缺乏的明显临床体征或症状。
The trace elements iron (Fe), copper (Cu), zinc (Zn), selenium (Se), chromium (Cr), manganese (Mn), nickel (Ni), rubidium (Rb), and bromine (Br) were determined in serum from 18 children, ages 4 to 65 months, who received long-term total parenteral nutrition (IPN). Nine patients (group 1) received TPN as their only source of nutrition; the other nine (group 2) ingested 30% to 70% of their total calorie requirement and received the remainder intravenously. The reference group consisted of 19 healthy children of similar age and sex distribution. Groups 1 and 2 had received parenteral nutrition for 28.4 .+-. 13.7 (SD) and 23.1 .+-. 17.1 (SD) months, respectively. All patients in group 1 and four in group 2 had short bowel syndrome; four in group 2 had pseudo-obstruction syndrome. Patients in group 1 had normal serum levels of Fe, Cu, and Mn, but increased levels of Zn; they had decreased serum concentrations of Se, Cr, Ni, Rb, and Br. Patients in group 2 had decreased serum levels of Mn, Cr, Ni, Rb, and Br. Those trace elements not supplemented in TPN solutions (Se, Cr, Mn, Ni, Rb, and Br) were lower in the children receiving TPN than in the control children, indicating inadequate intake of these trace elements from food and TPN solutions. However, no obvious clinical signs or symptoms of trace element deficiencies were observed.