Microengineered Emulsion-to-Powder Technology for the High-Fidelity Preservation of Molecular, Colloidal, and Bulk Properties of Hydrogel Suspensions
Microengineered Emulsion-to-Powder Technology for the High-Fidelity Preservation of Molecular, Colloidal, and Bulk Properties of Hydrogel Suspensions
复制标题
DOI：
10.1021/acsapm.9b00265
复制
发表时间：
2019-08-01
影响因子：
5
通讯作者：
Khademhosseini, Ali
中科院分区：
文献类型：
--
作者：
Sheikhi, Amir;Di Lisa, Donatella;Khademhosseini, Ali
含水微/纳米凝胶悬浮液仍然难以消毒、储存和运输。目前的技术，如冷冻干燥和喷雾干燥，显然不能保持凝胶颗粒的结构经历干燥。我们发明了微工程乳化制粉（MEtoP）技术，通过该技术，分散相在工程油/表面活性剂连续相中得到稳定和保护，然后进行冷冻和冻干。这种简单的方法将胶体系统，特别是可退火的水凝胶悬浮液，转化为粉末，在重悬时容易恢复其特性。MEtoP技术可以为软材料加工开辟新的领域，并为高保真的胶体到具有明确颗粒分布的粉末的转换奠定基础，用于广泛的先进应用。
Aqueous micro/nanogel suspensions remain difficult to sterilize, store, and ship. Current techniques such as freeze-drying and spray-drying have noticeably failed to preserve the structure of gel particles undergoing drying. We invented the microengineered emulsion-to-powder (MEtoP) technology via which a dispersed phase is stabilized and protected in an engineered oil/surfactant continuous phase, followed by freezing and lyophilization. This facile method converts colloidal systems, particularly annealable hydrogel suspensions, to powders that readily revive their properties upon resuspension. The MEtoP technology may open new horizons for soft material processing and set the stage for the high-fidelity conversion of colloids to powders with defined particle distributions for a broad spectrum of advanced applications.