Toxicity of different Fusarium mycotoxins on growth performance, immune responses and efficacy of a mycotoxin degrading enzyme in pigs
Toxicity of different Fusarium mycotoxins on growth performance, immune responses and efficacy of a mycotoxin degrading enzyme in pigs
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DOI：
10.1051/animres:2006032
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发表时间：
2006-11-01
期刊：
影响因子：
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通讯作者：
Chang, Ming-Huang
中科院分区：
文献类型：
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作者：
Cheng, Yeong-Hsiang;Weng, Ching-Feng;Chang, Ming-Huang
本试验旨在研究饲料中添加一定浓度的镰刀菌毒素脱氧雪腐镰刀菌烯醇（DON）和玉米赤霉烯酮（ZON）对猪生长性能、血液生化和免疫功能的影响，以及镰刀菌毒素降解酶（MDE）对镰刀菌毒素毒性的缓解作用。将48头断奶仔猪随机分配到4个处理组（每个处理组两个重复），包括对照组、毒素组（1 ppm DON和250 ppb ZON）、毒素+MDE组（1 ppm DON、250 ppb ZON和1.5 kg MDE/吨饲料）和单独MDE组（1.5 kg/吨饲料），进行为期6周的攻击试验。结果表明，DON和ZON暴露6周后，猪的生长性能、血清生化指标、肺泡巨噬细胞活性、伪狂犬病疫苗抗体滴度和细胞因子分泌谱均出现明显的损伤。基于这些发现，我们认为DON和ZON的组合赋予猪的化学多器官毒性，而MDE提供了真菌毒素的部分或完全毒性保留效果。
This study was aimed at investigating the effects of a defined concentration of Fusarium mycotoxins, deoxynivalenol (DON) and zearalenone (ZON) incorporated into feeds on growth performance, blood biochemistry, and immune response of pigs and the alleviating effects of a mycotoxin degrading enzyme (MDE) on the toxicity of Fusarium mycotoxins. A total of 48 weaning pigs was randomly allotted to four treatments (two replicates per treatment) including a control, Toxins (1 ppm DON and 250 ppb ZON), Toxin+MDE (1 ppm DON, 250 ppb ZON and 1.5 kg MDE per ton of feed), and MDE alone (1.5 kg per ton of feed) for a 6 week challenged trial. The results in different criteria including growth performance, serum biochemistry parameters, alveolar macrophage activity, antibody titers of pseudorabies (PR) vaccine and cytokine secretion profile showed that DON and ZON consistently impaired pigs after 6 week exposure. Based on these findings, we suggest that the combination of DON and ZON confers a chemical multi-organ toxicity in pigs and MDE provides a partial or complete toxic sparing effect of mycotoxins.