Fabrication of microfluidic mixers and artificial vasculatures using a high-brightness diode-pumped Nd:YAG laser direct write method
Fabrication of microfluidic mixers and artificial vasculatures using a high-brightness diode-pumped Nd:YAG laser direct write method
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DOI：
10.1039/b308452c
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发表时间：
2003-01-01
期刊：
影响因子：
6.1
通讯作者：
Takayama, S
中科院分区：
文献类型：
--
作者：
Lim, D;Kamotani, Y;Takayama, S
本文介绍了一种快速、灵活的激光直写技术，用于制作多级微流体通道。采用高亮度二极管泵浦的板条结构Nd-YAG激光器，获得了良好的光束质量。已成功地制造了具有平壁和交错的人字形脊的通道，并讨论了它们进行液体被动混合的能力。此外，已经制造了多宽度多深度微通道以产生仿生血管，其通道直径根据Murray定律变化，该定律规定母血管半径的立方等于子血管半径的立方之和。与生成均匀薄通道的平面图案化技术相比，多深度架构允许流动图案类似于生理血管系统，具有更低的总体阻力和在整个网络中更均匀的流速。使用相对简单的激光技术直接制造多级结构的能力增强了我们快速原型化复杂的芯片实验室系统和开发用于组织工程和生物医学流体问题研究的生理微流体结构的能力。
This paper describes a direct write laser technology, which is fast and flexible, for fabricating multiple-level microfluidic channels. A high brightness diode-pumped Nd-YAG laser with slab geometry was used for its excellent beam quality. Channels with flat walls and staggered herringbone ridges on the floor have been successfully fabricated and their ability to perform passive mixing of liquid is discussed. Also, a multi-width multi-depth microchannel has been fabricated to generate biomimetic vasculatures whose channel diameters change according to Murray's law, which states that the cube of the radius of a parent vessel equals the sum of the cubes of the radii of the daughters. The multi-depth architecture allows for flow patterns to resemble physiological vascular systems with lower overall resistance and more uniform flow velocities throughout the network compared to planar patterning techniques which generate uniformly thin channels. The ability to directly fabricate multiple level structures using relatively straightforward laser technology enhances our ability to rapidly prototype complex lab-on-a-chip systems and to develop physiological microfluidic structures for tissue engineering and investigations in biomedical fluidics problems.