Inhibition of Yin Yang 1-dependent repressor activity of DR5 transcription and expression by the novel proteasome inhibitor NPI-0052 contributes to its TRAIL-enhanced apoptosis in cancer cells (Retracted Article. See vol 197, pg 4860, 2016)
Inhibition of Yin Yang 1-dependent repressor activity of DR5 transcription and expression by the novel proteasome inhibitor NPI-0052 contributes to its TRAIL-enhanced apoptosis in cancer cells (Retracted Article. See vol 197, pg 4860, 2016)
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DOI：
10.4049/jimmunol.180.9.6199
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发表时间：
2008-05-01
影响因子：
4.4
通讯作者：
Bonavida, Benjamin
中科院分区：
文献类型：
--
作者：
Baritaki, Stavroula;Suzuki, Eriko;Bonavida, Benjamin
TRAIL促进肿瘤细胞凋亡；然而，trail耐药肿瘤需要增敏以逆转耐药。蛋白酶体抑制剂在体外和体内增强TRAIL细胞凋亡，并通过一种未知的机制与死亡受体5 （DR5）的上调相关。我们假设蛋白酶体抑制剂NPI-0052抑制转录抑制因子阴阳1 (YY1)， YY1调节TRAIL抗性，负调控DR5转录。NPI-0052对PC-3和Ramos细胞的作用
TRAIL promotes apoptotic tumor cell death; however, TRAIL-resistant tumors need to be sensitized to reverse resistance. Proteasome inhibitors potentiate TRAIL apoptosis in vitro and in vivo and correlate with up-regulation of death receptor 5 (DR5) via an unknown mechanism. We hypothesized that the proteasome inhibitor NPI-0052 inhibits the transcription repressor Yin Yang 1 (YY1) which regulates TRAIL resistance and negatively regulates DR5 transcription. Treatment of PC-3 and Ramos cells with NPI-0052 (