Health-related quality of life among patients with adenocarcinoma of the gastro-oesophageal junction treated by gastrectomy or oesophagectomy
Health-related quality of life among patients with adenocarcinoma of the gastro-oesophageal junction treated by gastrectomy or oesophagectomy
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DOI：
10.1002/bjs.5912
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发表时间：
2008-01-01
影响因子：
9.6
通讯作者：
Blazeby, J. M.
中科院分区：
文献类型：
--
作者：
Barbour, A. P.;Lagergren, P.;Blazeby, J. M.
背景：胃-食管交界处的肿瘤可通过全胃切除术（TG）或经胸食管切除术（TTO）切除。本研究比较了这些程序后与健康相关的生活质量（HRQL）。方法：收集63例连续的siwert I-III型胃食管肿瘤患者（TG 20例，TTO 43例）术前和术后6个月的前瞻性临床和HRQL数据（欧洲癌症研究与治疗组织QLQ-C30）。结果：问卷应答率超过90%。患者在疾病分期、治疗相关死亡率和生存率方面相似，但选择TTO的患者比接受TG的患者更年轻，合并症更少。这些差异反映在基线HRQL评分上，在选择TTO的患者中，HRQL评分更好。然而，手术后6个月，TTO后HRQL在角色和社会功能、整体生活质量和疲劳方面的恶化程度大于TG后。两组的疼痛和腹泻症状评分均有所增加。结论：TTO对胃-食管交界处肿瘤的HRQL的负面影响大于TG。
Background: Tumours of the gastro-oesophageal junction may be resected by total gastrectomy (TG) or transthoracic oesophagectomy (TTO). This study compared health-related quality of life (HRQL) following these procedures.Methods: Prospective clinical and HRQL data (European Organization for Research and Treatment of Cancer QLQ-C30) were collected from 63 consecutive patients (20 TG and 43 TTO) before and 6 months after surgery for Siewert type I-III gastro-oesophageal tumours.Results: Questionnaire response rates exceeded 90 per cent. Patients were similar with respect to disease stage, treatment-related mortality and survival, but those selected for TTO were younger with less co-morbidity than those undergoing TG. These differences were reflected in baseline HRQL scores, which were better in patients selected for TTO. Six months after surgery, however, HRQL showed a greater deterioration after TTO than after TG in terms of role and social function, global quality of life and fatigue. Symptom scores for pain and diarrhoea increased in both groups.Conclusion: TTO had a greater negative impact on HRQL than TG for tumours of the gastro-oesophageal junction.