Hepatic parenchymal enhancement at Gd-EOB-DTPA-enhanced MR imaging: correlation with morphological grading of severity in cirrhosis and chronic hepatitis
Hepatic parenchymal enhancement at Gd-EOB-DTPA-enhanced MR imaging: correlation with morphological grading of severity in cirrhosis and chronic hepatitis
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DOI：
10.1016/j.mri.2011.11.002
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发表时间：
2012-04-01
影响因子：
2.5
通讯作者：
Ito, Katsuyoshi
中科院分区：
文献类型：
--
作者：
Kanki, Akihiko;Tamada, Tsutomu;Ito, Katsuyoshi
目的是阐明钆-乙氧苄基-二乙烯三胺五乙酸（Gd-EOB-DTPA）增强MR成像肝胆期（HP）肝实质的增强效应是否与肝硬化严重程度的形态学分级相关。对62例慢性肝炎或肝硬化患者进行了Gd-EOB-DTPA增强MR成像。根据增强前图像（SIpre）和增强后20分钟HP图像（SIpost）获得的信号强度（SI）测量值计算肝实质的相对增强（RE）：（Slpost-SIpre）/SIpre。根据肝硬化严重程度的形态学MR分级分为四组。将肝实质RE值与MR分级进行相关性分析。根据肝硬化的形态学严重程度，MR 1级、2级、3级和4级患者的数量分别为14例（23%）、7例（11%）、28例（45%）和13例（21%）。MR形态学1、2、3和4级各组肝实质的平均RE分别为0.71 ± 0.21、0.62 ± 0.16、0.70 ± 0.22和0.77 ± 0.18。MRI形态学分级与20 min HP时肝实质RE无明显相关性。Gd-EOB-DTPA增强MR成像中HP的肝实质增强并不一定根据肝硬化形态学改变的严重程度而降低。这一事实可能表明，肝摄取Gd-EOB-DTPA取决于保存的肝细胞功能，而不是肝硬化的形态学变化的严重程度。(C)2012 Elsevier Inc. All rights reserved.
The aim was to clarify whether enhancement effects of the liver parenchyma in the hepatobiliary phase (HP) of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MR imaging were correlated with the morphological grading of the severity in cirrhosis. A total of 62 patients with chronic hepatitis or cirrhosis underwent Gd-EOB-DTPA-enhanced MR imaging. Relative enhancement (RE) of liver parenchyma was calculated from signal intensity (SI) measurements obtained at precontrast images (SIpre) and 20-min postcontrast HP images (SIpost) as: (Slpost-SIpre)/SIpre. Morphological MR grades of severity in cirrhosis were divided into four groups. Then, RE of liver parenchyma and morphologic MR grading were correlated. Regarding the morphologic severity of cirrhosis, the numbers of patients with MR grade 1, 2, 3 and 4 were 14(23%), 7(11%), 28(45%) and 13(21%), respectively. The mean REs of liver parenchyma in each group of MR morphologic grade 1, 2, 3 and 4 were 0.71 +/- 0.21, 0.62 +/- 0.16, 0.70 +/- 0.22 and 0.77 +/- 0.18, respectively. There was no significant correlation between the MR grading of morphologic severity and the RE of liver parenchyma at 20-min HP. Hepatic parenchymal enhancement in the HP of Gd-EOB-DTPA-enhanced MR imaging did not necessarily decrease according to the severity of morphologic changes in cirrhosis. This fact may suggest that the hepatic uptake of Gd-EOB-DTPA depends on the preserved hepatocytes function rather than the severity of morphologic changes in cirrhosis. (C) 2012 Elsevier Inc. All rights reserved.