Age-related changes in the vasculature of the dermis of the upper lip vermilion
Age-related changes in the vasculature of the dermis of the upper lip vermilion
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DOI：
10.18632/aging.101996
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发表时间：
2019-06-15
期刊：
影响因子：
5.2
通讯作者：
Imamura, Toru
中科院分区：
文献类型：
--
作者：
Gomi, Takamasa;Imamura, Toru
嘴唇发红是人类所特有的，会给人留下重要的面部印象，但这种发红会随着年龄的增长而减少。在这里，使用组织学和免疫组织化学染色的人上唇朱红从不同年龄的捐助者，我们调查血管在上唇真皮和年龄依赖性的组织学变化。我们发现，无论是总血管面积在真皮和血管数量在真皮上层随着年龄的增长而减少。此外，在上层真皮血管数量呈正相关的发展网脊，扁平化随着年龄的增长，尽管没有显着变化的复层鳞状上皮的厚度。这些研究结果表明，与年龄相关的嘴唇发红减少是由于血管减少，这反过来又导致上皮细胞因网脊丢失而变平。这是第一项从组织学上证明唇部血管与年龄相关的减少的研究。我们的研究结果提供了一个机会，提高血流/血管化，以改善老年人的嘴唇的美学外观。
Lip redness is unique to humans and creates an important facial impression, but this redness decreases with age. Here, using histological and immunohistological staining of human upper lip vermilion from donors of different ages, we investigated blood vessels in the upper lip dermis and age-dependent histological changes. We found that both total vessel area in the dermis and vessel number in the upper dermis decreased with aging. Moreover, vessel number in the upper dermis correlated positively with development of rete ridges, which flattened with age, despite no significant change in the thickness of the stratified squamous epithelium. These findings suggest that age-related reductions in lip redness result from a decrease of blood vessels, which in turn leads to a flattening of the epithelium caused by the loss of rete ridges. This is the first study to histologically demonstrate age-related reductions in blood vessels in the lip. Our results provide an opportunity for enhancing blood flow/vascularization to improve the aesthetic appearance of the lips in the elderly.