Use of non-parametric item response theory to develop a shortened version of the Positive and Negative Syndrome Scale (PANSS).
Use of non-parametric item response theory to develop a shortened version of the Positive and Negative Syndrome Scale (PANSS).
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DOI：
10.1186/1471-244x-11-178
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发表时间：
2011-11-16
期刊：
影响因子：
4.4
通讯作者：
Lindenmayer JP
中科院分区：
文献类型：
--
作者：
Khan A;Lewis C;Lindenmayer JP
使用非参数项目反应理论（IRT）检查（a）30个阳性和阴性症状量表（PANSS）项目及其选项（（严重程度））的性能，（B）区分症状严重程度差异的各种分量表的有效性，以及（c）基于IRT和将评分与原始PANSS联系起来的方法开发简化PANSS（Mini-PANSS）。从1995年至2005年参加精神药理学试验的7,187例精神分裂症或分裂情感性障碍患者中获得基线PANSS评分。构建选项特征曲线（OCC）和项目特征曲线（ICC），以检查30个PANSS项目中每个项目的7个选项中每个选项的评级概率，作为子量表严重程度的函数，并将总分链接应用于Mini-PANSS选择的项目。与一般精神病理学子量表相比，构成阳性和阴性子量表的大多数项目（即19个项目）表现非常好，并且沿着症状严重程度区分更好。7个阳性症状项目中的6个、7个阴性症状项目中的6个和16个一般精神病理学项目中的7个被保留以纳入Mini-PANSS。总分连接和线性插值能够生成转换表，用于比较Mini-PANSS的总分量表评分与原始PANSS的总分量表评分。结果表明，Mini-PANSS分量表的评分可以与原始PANSS分量表的评分相关联，偏差很小。该研究证明了非参数IRT在检查PANSS的项目属性中的实用性，并允许为简化的PANSS量表选择项目。30项PANSS和Mini-PANSS之间的比较显示，较短的版本与30项PANSS相当，但当应用IRT时，Mini-PANSS也是疾病严重程度的良好指标。
Nonparametric item response theory (IRT) was used to examine (a) the performance of the 30 Positive and Negative Syndrome Scale (PANSS) items and their options ((levels of severity), (b) the effectiveness of various subscales to discriminate among differences in symptom severity, and (c) the development of an abbreviated PANSS (Mini-PANSS) based on IRT and a method to link scores to the original PANSS. Baseline PANSS scores from 7,187 patients with Schizophrenia or Schizoaffective disorder who were enrolled between 1995 and 2005 in psychopharmacology trials were obtained. Option characteristic curves (OCCs) and Item Characteristic Curves (ICCs) were constructed to examine the probability of rating each of seven options within each of 30 PANSS items as a function of subscale severity, and summed-score linking was applied to items selected for the Mini-PANSS. The majority of items forming the Positive and Negative subscales (i.e. 19 items) performed very well and discriminate better along symptom severity compared to the General Psychopathology subscale. Six of the seven Positive Symptom items, six of the seven Negative Symptom items, and seven out of the 16 General Psychopathology items were retained for inclusion in the Mini-PANSS. Summed score linking and linear interpolation was able to produce a translation table for comparing total subscale scores of the Mini-PANSS to total subscale scores on the original PANSS. Results show scores on the subscales of the Mini-PANSS can be linked to scores on the original PANSS subscales, with very little bias. The study demonstrated the utility of non-parametric IRT in examining the item properties of the PANSS and to allow selection of items for an abbreviated PANSS scale. The comparisons between the 30-item PANSS and the Mini-PANSS revealed that the shorter version is comparable to the 30-item PANSS, but when applying IRT, the Mini-PANSS is also a good indicator of illness severity.