Role of RAP in the biogenesis of lipoprotein receptors
Role of RAP in the biogenesis of lipoprotein receptors
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DOI：
10.1016/s1050-1738(00)00045-1
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发表时间：
2000-05-01
影响因子：
9.3
通讯作者：
Marzolo, MP
中科院分区：
文献类型：
--
作者：
Bu, GJ;Marzolo, MP
低密度脂蛋白受体基因家族由几个内吞受体组成，它们在细胞摄取包括脂蛋白颗粒在内的各种配体方面具有结构同源性和功能。富含半胱氨酸的配体结合重复序列的存在突出了这些脂蛋白受体的复杂结构。所有这些受体的一个重要特征是39 kda受体相关蛋白（RAP）对配体相互作用的抑制。最近的研究表明，在生理条件下，RAP作为分子伴侣，协助脂蛋白受体折叠并安全通过分泌途径。关于RAP作为配体与受体相互作用的拮抗剂和早期分泌途径中的分子伴侣的分子机制，已经提出了几个非排他性的模型。阐明这些机制可能有助于了解在生理和病理条件下如何通过RAP的表达来调节脂蛋白受体的生物发生。（心血管医学趋势2000；10:148-155）。(C) 2001爱思唯尔科学公司
The LDL receptor gene family is composed of several endocytic receptors that share structural homology and function in cellular uptake of various ligands including lipoprotein particles. The complex structure of these lipoprotein receptors is highlighted by the presence of clusters of cysteine-rich ligand-binding repeats. An important feature that is shaved by all these receptors is the inhibition of ligand interaction by a 39-kDa receptor-associated protein (RAP). Recent studies have shown that under physiological conditions RAP serves as a molecular chaperone to assist the folding of lipoprotein receptors and their safe passage through the secretory pathway. Several non-exclusive models have been proposed regarding the molecular mechanisms of RAP function as an antagonist for ligand interaction with the receptors and as a molecular chaperone within the early secretory pathway. Elucidation of these mechanisms may provide insights into how biogenesis of lipoprotein receptors can be regulated via the expression of RAP under physiological and pathological conditions. (Trends Cardiovasc Med 2000;10:148-155). (C) 2001 Elsevier Science Inc.