Improvement of the Biodegradation Property and Biomineralization Ability of Magnesium-Hydroxyapatite Composites with Dicalcium Phosphate Dihydrate and Hydroxyapatite Coatings
Improvement of the Biodegradation Property and Biomineralization Ability of Magnesium-Hydroxyapatite Composites with Dicalcium Phosphate Dihydrate and Hydroxyapatite Coatings
复制标题
DOI：
10.1021/acsbiomaterials.6b00013
复制
发表时间：
2016-05-01
影响因子：
5.8
通讯作者：
Li, Guangyu
中科院分区：
文献类型：
--
作者：
Su, Yingchao;Li, Dayong;Li, Guangyu
磷酸钙增强镁基复合材料的应用至今未能达到控制镁降解率的预期效果。因此，为了提高复合材料的耐蚀性，进一步发展其表面生物活性，以满足骨组织工程应用的特定要求，分别采用简单转化涂层法和后续碱后处理的方法，在自制的HA/Mg复合材料上沉积生物相容性磷酸钙二水合物（DCPD）涂层和羟基磷灰石（HA）涂层。通过对比复合材料、纯Mg和AZ60镁合金的包覆工艺，研究了转化包覆机理。电化学结果表明，最佳DCPD和HA涂层的极化电阻分别是复合材料的15倍和65倍左右。模拟体液浸泡试验表明，这两种涂层都能提高HA/Mg复合材料的耐腐蚀性和生物矿化能力。
The application of calcium phosphate reinforced magnesium matrix composites has not achieved the expected effect to control the degradation rate of magnesium so far. Therefore, in order to enhance the corrosion resistance and further develop the surface bioactivity of the composites to meet specific requirements of bone tissue engineering applications, biocompatible dicalcium phosphate dihydrate (DCPD) and hydroxyapatite (HA) coatings have been deposited on homemade HA/Mg composites using a simple conversion coating method and a subsequent alkali post-treatment, respectively. The conversion coating mechanism was studied by comparing coating processes on the composites, pure Mg, and an AZ60 Mg alloy. Electrochemical results showed that polarization resistance of the optimum DCPD and HA coatings was about 15 and 65 times higher than that of the composites, respectively. Immersion tests in simulated body fluid revealed that both coatings could supply improved corrosion resistance and biomineralization ability for the HA/Mg composites.