Locomotor activity correlates with modifications of hippocampal mossy fibre synaptic transmission
Locomotor activity correlates with modifications of hippocampal mossy fibre synaptic transmission
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DOI：
10.1111/j.1460-9568.2006.05079.x
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发表时间：
2006-10-01
影响因子：
3.4
通讯作者：
Suzuki, Hidenori
中科院分区：
文献类型：
--
作者：
Kobayashi, Katsunori;Ikeda, Yumiko;Suzuki, Hidenori
海马体长期以来一直与记忆的形成有关。虽然越来越多的证据表明海马参与了其他脑功能，包括运动调节和情绪过程，但这些功能背后的细胞和突触基础仍然很大程度上未知。我们在这里报告，在小鼠的环境操作揭示了协会的运动活动与海马苔藓纤维（MF）突触传递。突触反应的电生理记录是用从行为分析过的小鼠身上制备的海马切片进行的。环境丰富诱导平行减少开放领域的运动活动和MF突触促进。在相对较长的间隔（>= 200 ms）的配对脉冲刺激诱导的易化选择性减少，而基础突触功效和高频传输不受影响。社会隔离引起了行为的变化，在高架十字迷宫，但无论是开放领域的活动，也没有MF突触传递显着改变。多巴胺，运动调节所必需的神经递质，对MF突触的影响也使用这些小鼠进行了检查。环境操作并没有引起显着的变化，多巴胺诱导的MF突触传递增强。然而，在个别科目的行为和电生理结果的分析表明，自发活动与多巴胺诱导的增强幅度呈负相关。这些结果表明，MF突触在运动活动的调节中起重要作用。我们建议，MF突触可以作为某些形式的运动调节的突触模型，具有潜在的重要性，精神疾病的病理生理学研究使用动物模型。
The hippocampus has long been implicated in memory formation. Although accumulating evidence suggests involvement of the hippocampus in other brain functions including locomotor regulation and emotional processes, cellular and synaptic bases underlying these functions remain largely unknown. We here report that environmental manipulations in mice unveiled the association of locomotor activity with the hippocampal mossy fibre (MF) synaptic transmission. Electrophysiological recordings of synaptic responses were made using hippocampal slices prepared from mice whose behaviour had been analysed. Environmental enrichment induced parallel decreases in open-field locomotor activity and MF synaptic facilitation. Facilitation induced by paired-pulse stimulation at relatively long intervals (>= 200 ms) was selectively reduced while the basal synaptic efficacy and high-frequency transmission were unaffected. Social isolation caused a change in behaviour in an elevated plus-maze, but neither the open-field activity nor the MF synaptic transmission was significantly altered. Effects of dopamine, a neurotransmitter essential for locomotor regulation, on the MF synapse were also examined using these mice. Environmental manipulations did not cause significant changes in potentiation of the MF synaptic transmission induced by dopamine. However, analysis of behavioural and electrophysiological results in individual subjects revealed that locomotor activity negatively correlates with magnitude of the dopamine-induced potentiation. These results suggest that the MF synapse plays important roles in the regulation of locomotor activity. We propose that the MF synapse can serve as the synaptic model for certain forms of locomotor regulation, with potential importance for investigation of the pathophysiology of psychiatric diseases using animal models.