Behavioral and Neural Effects of Nicotine on Visuospatial Attentional Reorienting in Non-Smoking Subjects
Behavioral and Neural Effects of Nicotine on Visuospatial Attentional Reorienting in Non-Smoking Subjects
复制标题
尼古丁对非吸烟受试者视觉空间注意力重新定向的行为和神经影响
DOI：
10.1038/sj.npp.1301469
复制
发表时间：
2008
影响因子：
7.6
通讯作者：
G. Fink
中科院分区：
文献类型：
--
作者：
S. Vossel;C. Thiel;G. Fink
胆碱能神经递质系统被认为参与位置线索范式中由内源性线索提供的概率自上而下信息的处理。研究表明，尼古丁胆碱能刺激的行为和神经效应与操纵空间线索有效性的效果相似：提高皮质尼古丁水平和降低线索有效性都会减少无效和有效线索目标之间的反应时差(即“有效性效应”)，以及与顶脑区域注意重新定向相关的神经活动。在本研究中，我们调查了尼古丁在位置线索范式中的行为和神经效应是否依赖于不同的先验线索有效性。24名受试者采用双盲、安慰剂对照、受试者间设计和功能磁共振成像进行研究。尼古丁通过Polacrilex口香糖(Nicorette®，2 mg)给不吸烟的志愿者服用，然后在MR扫描仪中进行90%和60%线索有效性的位置提示范例。尼古丁在90%的线索效度条件下显著降低了效度效应，而在60%的线索效度条件下则不显著。额顶区和扣带区在高线索有效性条件下比在低线索有效性条件下表现出更强的重定向相关神经活动的烟碱减少。我们的数据揭示了注意重定向的药理学和认知调节之间的交互作用，这在行为和神经水平上都是明显的。
The cholinergic neurotransmitter system has been proposed to be involved in the processing of probabilistic top-down information provided by endogenous cues in location-cueing paradigms. It has been shown that the behavioral and neural effects of a nicotinic cholinergic stimulation resemble the effects obtained by manipulating the validity of the spatial cues: enhancing cortical nicotine levels and decreasing cue validity both reduce the reaction time difference between invalidly and validly cued targets (ie, the ‘validity effect’) as well as neural activity related to attentional reorienting in parietal brain regions. In the present study, we investigated whether the behavioral and neural effects of nicotine in location-cueing paradigms are dependent upon different a priori cue validities. Twenty-four subjects were investigated in a double-blind placebo-controlled between-subject design with functional magnetic resonance imaging. Nicotine was administered to non-smoking volunteers via polacrilex gums (Nicorette®, 2 mg) before performing a location-cueing paradigm with valid and invalid cues in the context of 90 and 60% cue validity in the MR scanner. Nicotine significantly reduced the validity effect in the 90% but not in the 60% cue validity condition. Fronto-parietal and cingulate regions showed stronger nicotinic reductions of reorienting-related neural activity in the high than in the low cue validity condition. Our data reveal an interaction effect between the pharmacological and cognitive modulation of attentional reorienting, which is evident at both a behavioral as well as the neuronal level.
选择性注意和视觉搜索：分配模型的修订及其对年龄差异的应用。
DOI：
10.1037//0096-1523.18.3.821
发表时间：
1992
期刊：
Journal of experimental psychology. Human perception and performance
影响因子：
--
作者：
Madden,DJ
通讯作者：
Madden,DJ
DOI：
10.1037/0096-1523.11.5.583
发表时间：
1985-01-01
影响因子：
2.1
作者：
ERIKSEN, CW;YEH, YY
通讯作者：
YEH, YY