The Mechanism of Facultative Intracellular Parasitism of Brucella.
The Mechanism of Facultative Intracellular Parasitism of Brucella.
复制标题
布鲁氏菌兼性细胞内寄生机制
DOI：
10.3390/ijms22073673
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发表时间：
2021-04-01
影响因子：
5.6
通讯作者：
Gu G
中科院分区：
文献类型：
--
作者：
Jiao H;Zhou Z;Li B;Xiao Y;Li M;Zeng H;Guo X;Gu G
布鲁氏菌病是一种以妊娠动物流产和生殖功能障碍为特征的高度流行的人畜共患疾病。布鲁氏菌病虽然死亡率低，但危害人类健康，也严重影响畜牧业、旅游业和国际贸易的发展。布鲁氏菌病是由布鲁氏菌引起的，是一种兼性的胞内寄生细菌。它主要在宿主细胞内形成含布鲁氏菌的空泡(BCV)，以避免与溶酶体(Lys)结合，从而避免被宿主免疫系统清除。布鲁氏菌不仅具有抵抗吞噬杀菌作用的能力，还能使宿主细胞形成有利于其生存、繁殖和复制的微环境，并在宿主细胞内长期存活，最终导致慢性持续性感染的形成。布鲁氏菌可以在细胞内增殖和复制，逃避宿主免疫反应，诱导持续感染，是布鲁氏菌病治疗和预防中的难题。因此，本文对布鲁氏菌的兼性细胞内寄生和免疫逃逸机制进行了初步的综述，为以后研究布鲁氏菌的致病机理提供了理论依据。
Brucellosis is a highly prevalent zoonotic disease characterized by abortion and reproductive dysfunction in pregnant animals. Although the mortality rate of Brucellosis is low, it is harmful to human health, and also seriously affects the development of animal husbandry, tourism and international trade. Brucellosis is caused by Brucella, which is a facultative intracellular parasitic bacteria. It mainly forms Brucella-containing vacuoles (BCV) in the host cell to avoid the combination with lysosome (Lys), so as to avoid the elimination of it by the host immune system. Brucella not only has the ability to resist the phagocytic bactericidal effect, but also can make the host cells form a microenvironment which is conducive to its survival, reproduction and replication, and survive in the host cells for a long time, which eventually leads to the formation of chronic persistent infection. Brucella can proliferate and replicate in cells, evade host immune response and induce persistent infection, which are difficult problems in the treatment and prevention of Brucellosis. Therefore, the paper provides a preliminary overview of the facultative intracellular parasitic and immune escape mechanisms of Brucella, which provides a theoretical basis for the later study on the pathogenesis of Brucella.
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影响因子：
3.7
作者：
Durward M;Radhakrishnan G;Harms J;Bareiss C;Magnani D;Splitter GA
通讯作者：
Splitter GA
影响因子：
3.1
作者：
Chain, PSG;Comerci, DJ;Garcia, E
通讯作者：
Garcia, E
DOI：
10.1073/pnas.0502040102
发表时间：
2005-06-28
影响因子：
11.1
作者：
Andersen-Nissen, E;Smith, KD;Aderem, A
通讯作者：
Aderem, A
影响因子：
3.1
作者：
Bellaire, BH;Elzer, PH;Roop, RM
通讯作者：
Roop, RM
DOI：
10.1084/jem.20030088
发表时间：
2003-08-18
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Celli J;de Chastellier C;Franchini DM;Pizarro-Cerda J;Moreno E;Gorvel JP
通讯作者：
Gorvel JP