Lesions of the fusiform, face area impair perception of facial configuration in prosopagnosia
Lesions of the fusiform, face area impair perception of facial configuration in prosopagnosia
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DOI：
10.1212/wnl.58.1.71
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发表时间：
2002-01-08
期刊：
影响因子：
9.9
通讯作者：
O'Connor, M
中科院分区：
文献类型：
--
作者：
Barton, JJS;Press, DZ;O'Connor, M
背景：面孔失认症，即无法识别面孔，与内侧枕颞损伤有关，尤其是右侧。功能成像显示右侧梭状回的一个焦点区域在面部感知过程中被激活。目的：本研究试图确定该区域的病变是否与面孔失认症患者的面部感知缺陷有关。方法：对5例获得性面孔失认症患者进行检测。他们被要求辨别那些面部特征的空间结构被改变的面孔。这与他们对特征颜色变化的辨别形成对比，特征颜色的变化不影响空间关系。结果：4例包括右侧梭状回颜面区的患者在识别特征空间位置变化方面均严重受损。一名双侧前部病变的患者在这种感知能力上是正常的。对于5名患者中的3名，眼睛颜色变化的准确性是正常的。当受试者知道只会显示嘴位的变化时，在最初的测试中受损的四名患者中，有两名的表现明显改善。结论：当右侧梭状回受损时，面孔失认症患者的面部形态知觉受损。当注意力必须分散在许多面部元素上时，这种缺陷尤其明显。它不会发生在更多的双侧颞前部病变。这种能力的丧失可能导致某些形式的面孔失认症的识别缺陷。
Background: Prosopagnosia, the inability to recognize faces, is associated with medial occipitotemporal lesions, especially on the right. Functional imaging has revealed a focal region in the right fusiform gyrus activated specifically during face perception. Objective: The study attempted to determine whether lesions of this region were associated with defects in face perception in patients with prosopagnosia. Methods: Five patients with acquired prosopagnosia were tested. They were asked to discriminate faces in which the spatial configuration of features had been altered. This was contrasted with their discrimination of changes in feature color, an alteration that does not affect spatial relations. Results: All four patients whose lesions included the right fusiform face area were severely impaired in discriminating changes in the spatial position of features. The one patient with anterior bilateral lesions was normal in this perceptual ability. For three of the five patients, accuracy was normal for changes in eye color. V hen subjects knew that only changes in mouth position would be shown, performance improved markedly in two of the four patients who were impaired in the initial test. Conclusion: Perception of facial configuration is impaired in patients with prosopagnosia whose lesions involve the right fusiform gyrus. This deficit is especially manifest when attention must be distributed across numerous facial elements. It does not occur with more anterior bilateral temporal lesions. Loss of this ability may contribute to the recognition defect in some forms of prosopagnosia.