Study of surfactant-skin interactions by skin impedance measurements
Study of surfactant-skin interactions by skin impedance measurements
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DOI：
10.1111/j.1468-2494.2011.00683.x
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发表时间：
2012-02-01
影响因子：
2.3
通讯作者：
Moore, David J.
中科院分区：
文献类型：
--
作者：
Lu, Guojin;Moore, David J.
角质层（SC）作为皮肤屏障在调节通过皮肤的水分损失和保护身体免受广泛的物理和化学外源性损伤方面起着非常关键的生理作用。由于表面活性剂的吸收和渗透，含有表面活性剂的制剂可引起皮肤损伤和刺激。通常认为，皮肤屏障性能的降低仅在表面活性剂已经渗透/渗透到皮肤屏障中之后发生。为了减轻基于表面活性剂的清洁产品的粗糙感，应减少表面活性剂的渗透/渗透。使用垂直Franz扩散池在体外对猪皮肤进行皮肤阻抗测量，以研究表面活性剂、温度和pH对皮肤屏障完整性的影响。这些皮肤阻抗结果表明，与其他已发表的用于评估不同表面活性剂化学性质、浓度、pH值、暴露时间和温度引起的皮肤损伤和刺激的方法具有良好的相关性。本研究表明，皮肤阻抗可用作筛选含表面活性剂制剂的常规方法，以确定其损害皮肤屏障的倾向，因此可能导致皮肤刺激。
The stratum corneum (SC) plays a very critical physiological role as skin barrier in regulating water loss through the skin and protects the body from a wide range of physical and chemical exogenous insults. Surfactant-containing formulations can induce skin damage and irritation owing to surfactant absorption and penetration. It is generally accepted that reduction in skin barrier properties occurs only after surfactants have penetrated/permeated into the skin barrier. To mitigate the harshness of surfactant-based cleansing products, penetration/permeation of surfactants should be reduced. Skin impedance measurements have been taken in vitro on porcine skin using vertical Franz diffusion cells to investigate the impact of surfactants, temperature and pH on skin barrier integrity. These skin impedance results demonstrate excellent correlation with other published methods for assessing skin damage and irritation from different surfactant chemistry, concentration, pH, time of exposure and temperature. This study demonstrates that skin impedance can be utilized as a routine approach to screen surfactant-containing formulations for their propensity to compromise the skin barrier and hence likely lead to skin irritation.