Accommodative changes in human eye observed by Kitasato anterior segment optical coherence tomography
Accommodative changes in human eye observed by Kitasato anterior segment optical coherence tomography
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DOI：
10.1007/s10384-012-0208-6
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发表时间：
2013-04
影响因子：
2.4
通讯作者：
N. Satoh;K. Shimizu;A. Goto;A. Igarashi;K. Kamiya;K. Ohbayashi
中科院分区：
文献类型：
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作者：
N. Satoh;K. Shimizu;A. Goto;A. Igarashi;K. Kamiya;K. Ohbayashi
目的利用扫描源光学相干断层扫描技术（Kitasato前段OCT/KAs-OCT）研究人体晶状体的适应性变化，该技术可对整个眼前段进行成像。方法招募健康受试者35例，平均年龄41岁，年龄13 ~ 79岁。使用as - oct，我们测量了远（0.4 D）和近（10 D）调节刺激下晶状体前（ASC）和后表面（PSC）的曲率、晶状体厚度（LT）和前房深度（ACD）。结果调节刺激反应（0.4/10 D）的平均值±标准差为：ASC半径为9.72±2.53/7.84±1.85 mm (Wilcoxon秩号检验，p< 0.0001)；PSC半径5.06±0.71/4.70±0.76毫米(p = 0.0012);LT, 3.86±0.77/4.00±0.76 mm (p< 0.0001)；ACD: 2.72±0.61/2.61±0.54 mm （p= 0.0002）。ASC、LT和ACD的调节相关变化率与年龄有显著相关性（Pearson相关系数分别为r= - 0.725,p< 0.0001;r= - 0.626,p= 0.0001;r= - 0.720,p< 0.0001），而PSC与年龄无显著相关性（r= - 0.064,p= 0.401）。结论ASC和PSC的半径随调节而减小，且ASC的变化速率大于PSC。
PurposeTo study accommodative changes in the human lens using swept-source optical coherence tomography (Kitasato anterior segment OCT/KAs-OCT), which can image the whole anterior segment of the eye.MethodsThirty-five healthy subjects (mean age 41 years, range 13–79 years) were recruited. Using KAs-OCT, we measured the curvature of the anterior (ASC) and posterior surfaces (PSC), the thickness (LT) of the lens and the anterior chamber depth (ACD) in response to far (0.4 D) and near (10 D) accommodative stimuli.ResultsIn response to accommodative stimuli (0.4/10 D), the mean values ± standard deviations were: radius of ASC, 9.72 ± 2.53/7.84 ± 1.85 mm (Wilcoxon ranked-sign test,p< 0.0001); radius of PSC, 5.06 ± 0.71/4.70 ± 0.76 mm (p= 0.0012); LT, 3.86 ± 0.77/4.00 ± 0.76 mm (p< 0.0001); ACD, 2.72 ± 0.61/2.61 ± 0.54 mm (p= 0.0002). The rate of accommodation-associated changes in ASC, LT, and ACD showed significant correlation with aging (Pearson correlation coefficient:r= −0.725,p< 0.0001;r= −0.626,p= 0.0001;r= −0.720,p< 0.0001, respectively), but there was no such correlation in PSC (r= −0.064,p= 0.401).ConclusionThe radius of ASC and PSC decreased with accommodation, and the rates of changes in ASC were larger than those in PSC.