Novel sol-gel preparation of (P2O5)0.4-(CaO)0.25-(Na2O)X-(TiO2)(0.35-X) bioresorbable glasses (X=0.05, 0.1, and 0.15)
Novel sol-gel preparation of (P2O5)0.4-(CaO)0.25-(Na2O)X-(TiO2)(0.35-X) bioresorbable glasses (X=0.05, 0.1, and 0.15)
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DOI：
10.1007/s10971-014-3555-6
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发表时间：
2015-02-01
影响因子：
2.5
通讯作者：
Knowles, Jonathan C.
中科院分区：
文献类型：
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作者：
Foroutan, Farzad;de Leeuw, Nora H.;Knowles, Jonathan C.
采用溶胶-凝胶法成功地合成了P_2O_5-CaO-Na_2 O-TiO_2系统的四元磷酸盐玻璃，其中P_2O_5和CaO的含量分别为40mol%和25mol%。稳定的溶胶-凝胶玻璃的结构，元素比例和热性能的特征在于使用X射线衍射（XRD），能量色散X射线光谱（EDX），P-31核磁共振（P-31 NMR），钛K边X射线吸收近边结构（XANES），傅立叶变换红外（FTIR）光谱，和差热分析（DTA）。XRD结果证实了所有稳定的溶胶-凝胶衍生的玻璃的无定形性质。EDX结果表明，在溶胶-凝胶过程中磷的损失相对较低，Ti K-边XANES证实了玻璃结构中的钛主要处于六重配位环境。P-31 NMR和FTIR结果表明，玻璃结构主要由Q（1）和Q（2）磷酸盐单元组成，Ti ~（4+）离子在磷酸盐单元之间起交联作用。此外，DTA结果证实了玻璃化转变温度和结晶温度随Na 2 O含量的增加而降低。离子释放研究还表明，随着TiO 2含量的增加，降解速率降低，因此支持将这些玻璃用于需要一定程度控制玻璃降解的生物医学应用。这些溶胶-凝胶玻璃也提供了潜在的纳入积极分子的药物输送应用，由于低合成温度。
Quaternary phosphate-based glasses in the P2O5-CaO-Na2O-TiO2 system with a fixed P2O5 and CaO content of 40 and 25 mol% respectively have been successfully synthesised via sol-gel method and bulk, transparent samples were obtained. The structure, elemental proportion, and thermal properties of stabilised sol-gel glasses have been characterised using X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDX), P-31 nuclear magnetic resonance (P-31 NMR), titanium K-edge X-ray absorption near-edge structure (XANES), fourier transform infrared (FTIR) spectroscopy, and differential thermal analysis (DTA). The XRD results confirmed the amorphous nature for all stabilized sol-gel derived glasses. The EDX result shows the relatively low loss of phosphorus during the sol-gel process and Ti K-edge XANES confirmed titanium in the glass structure is in mainly six-fold coordination environment. The P-31 NMR and FTIR results revealed that the glass structure consist of mainly Q(1) and Q(2) phosphate units and the Ti4+ cation was acting as a cross-linking between phosphate units. In addition DTA results confirmed a decrease in the glass transition and crystallisation temperature with increasing Na2O content. Ion release studies also demonstrated a decrease in degradation rates with increasing TiO2 content therefore supporting the use of these glasses for biomedical applications that require a degree of control over glass degradation. These sol-gel glasses also offer the potential to incorporate proactive molecules for drug delivery application due to the low synthesis temperature employed.