Extended amygdala and emotional salience: A PET activation study of positive and negative affect
Extended amygdala and emotional salience: A PET activation study of positive and negative affect
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DOI：
10.1038/sj.npp.1300113
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发表时间：
2003-04-01
影响因子：
7.6
通讯作者：
Taylor, SF
中科院分区：
文献类型：
--
作者：
Liberzon, I;Phan, KL;Taylor, SF
功能神经成像研究表明，杏仁核和基底前脑区域，包括豆状核下延伸的杏仁核(SLEA)，参与调节厌恶情绪反应。然而，目前尚不清楚Slea是对“厌恶”做出反应，还是对普遍的刺激突显做出反应。我们预测，愉快和厌恶的刺激都会激活这一区域。使用[O-15]水坑，我们研究了10名健康受试者在观看愉悦、厌恶、中性和空白图像的情况下。每个受试者都接受了八次扫描，并用标准的统计方法进行了处理和平均。无论是正面还是负面刺激都会激活Shea中的区域。正面和负面内容都激活了视觉皮质，相对于中性内容，厌恶刺激相对于正面和中性刺激抑制了左侧额叶极点。这些发现表明，积极和消极的情绪内容都会在豆状核下/杏仁核延长区引发加工，这表明该区域参与了一般的情绪加工。例如显著程度的检测或归因。
Functional neuroimaging studies have implicated amygdaloid and basal forebrain regions, including sublenticular extended amygdala (SLEA), in the mediation of aversive emotional responses. However, it is not clear whether SLEA responds to 'aversiveness' or to general stimulus salience. We predicted that both pleasant and aversive stimuli would activate this region. Using [O-15] water PIT, we studied 10 healthy subjects while viewing pleasant, aversive, neutral, and blank images. Each subject underwent eight scans, which were processed and averaged with standard statistical methods. Both positive and negative stimuli activated regions in SHEA. Both positive and negative content activated the visual cortex, relative to neutral content, Aversive stimuli deactivated the left frontal pole, relative to positive and neutral stimuli. These findings demonstrate that both positive and negative emotional content evokes processing in the sublenticular/ extended amygdala region, suggesting that this region is involved in general emotional processing. such as detection or attribution of salience.