D1/D5 RECEPTOR AGONISTS INDUCE A PROTEIN SYNTHESIS-DEPENDENT LATE POTENTIATION IN THE CA1 REGION OF THE HIPPOCAMPUS
D1/D5 RECEPTOR AGONISTS INDUCE A PROTEIN SYNTHESIS-DEPENDENT LATE POTENTIATION IN THE CA1 REGION OF THE HIPPOCAMPUS
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DOI：
10.1073/pnas.92.7.2446
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发表时间：
1995-03-28
影响因子：
11.1
通讯作者：
KANDEL, ER
中科院分区：
文献类型：
--
作者：
HUANG, YY;KANDEL, ER
与腺苷酸环化酶正偶联的多巴胺D1/D5受体激动剂特异性诱导海马CA 1区场兴奋性突触后电位的缓慢发展的持久增强，持续时间>6小时，这种增强被特异性D1/D5受体拮抗剂SCH 23390阻断，并被cAMP激动剂诱导的增强所阻断。通过G（α 1）与腺苷酸环化酶负偶联的D2受体激动剂不诱导增强作用，尽管这种缓慢的D1/D5激动剂诱导的增强作用部分地不依赖于N-甲基-D-天冬氨酸受体，它似乎与长时程增强（LTP）的晚期相共享一些步骤，并被LTP的晚期相阻断由施加于Schaffer侧支通路的三个重复的神经刺激序列产生。类似地，D1/D5拮抗剂SCH 23390减弱由重复序列诱导的LTP的晚期，并且D1/D5激动剂诱导的增强被蛋白质合成抑制剂茴香霉素阻断。这些结果表明，D1/D5受体可能参与海马CA 1区LTP的晚期、蛋白质合成依赖性成分，作为辅助成分或作为直接促进晚期相的介质，
Agonists of the dopamine D1/D5 receptors that are positively coupled to adenylyl cyclase specifically induce a slowly developing long-lasting potentiation of the field excitatory postsynaptic potential in the CA1 region of the hippocampus that lasts for >6 hr. This potentiation is blocked by the specific D1/D5 receptor antagonist SCH 23390 and is occluded bg the potentiation induced by cAMP agonists. An agonist of the D2 receptor, which is negatively coupled to adenylyl cyclase through G(alpha i), did not induce potentiation, Although this slow D1/D5 agonist-induced potentiation is partially independent of N-methyl-D-aspartate receptors, it seems to share some steps with and is occluded by the late phase of long-term potentiation (LTP) produced by three repeated trains of nerve stimuli applied to the Schaffer collateral pathway. Similarly, the D1/D5 antagonist SCH 23390 attenuates the late phase of the LTP induced by repeated trains, and the D1/D5 agonist-induced potentiation is blocked by the protein synthesis inhibitor anisomycin. These results suggest that the D1/D5 receptor mag be involved in the late, protein synthesis-dependent component of LTP in the hippocampal CA1 region, either as an ancillary component or as a mediator directly contributing to the late phase,